ID Card:
| Full name: |
23S rRNA (Uracil-C(5))-methyltransferase RlmCD |
| GI: |
2034612541
|
| Orf: |
SpnNT_01953 |
| Enzyme type: |
methyltransferase |
Protein sequence:
MHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKKV
Comments:
RlmCD encoded by SP_1029 in S. pneumoniae is responsible for C5-methylation of U747 and U1939. Methylation of 23S rRNA by the dual-specific methyltransferase, RlmCD, guides the 23S rRNA efficiently to sequential methylation by the other methyltransferase, RlmAII, rendering S. pneumoniae TEL susceptible.
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithr |
Shoji T, Takaya A, Sato Y, Kimura S, Suzuki T, Yamamoto T |
Nucleic Acids Res |
[details]
|
26365244
|
10.1093/nar/gkv609
|