Modomics - A Database of RNA Modifications

ID Card:

Full name: cytosolic thiouridylase subunit 1 - Cytoplasmic tRNA 2-thiolation protein 1
Synonym: MGC17332, NCS6
GI: 74713747
UniProt: Q7Z7A3
Alpha Fold Predicted Structure: AF-Q7Z7A3-F1
Enzyme type: thiolase



Protein sequence:

MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASGGKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARRVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF

Comments:

It is speculated how URM1could contribute as a sulfur donor for the thiolation of tRNAGlnUUG, tRNAGluUUC, and tRNALysUUU allowing for the catalysis of tRNA adenylation, an intermediate that is required for 2-thiolation. Deletion of URM1 causes an increased mobility of tRNAGlnUUG, tRNAGluUUC, tRNALysUUU thus indicating the pivotal role of CTU1 in the 2-thiolation of the wobble positions of these three tRNAs (Schlieker et al. 2008 ).





Alpha Fold Predicted Structure:




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Protein sequence:

M P A P P C A S C H A A R A A L R R P L S G Q A L C G A C F C A A F E A E V L H T V L A G R L L P P G A V V A V G A S G G K D S T V L A H V L R A L A P R L G I S L Q L V A V D E G I G G Y R D A A L A A V R R Q A A R W E L P L T V V A Y E D L F G G W T M D A V A R S T A G S G R S R S C C T F C G V L R R R A L E E G A R R V G A T H I V T G H N A D D M A E T V L M N F L R G D A G R L A R G G G L G S P G E G G A L P R C R P L Q F A S Q K E V V L Y A H F R R L D Y F S E E C V Y A P E A F R G H A R D L L K R L E A A R P S A V L D L V H S A E R L A L A P A A R P P R P G A C S R C G A L A S R A L C Q A C A L L D G L N R G R P R L A I G K G R R G L D E E A T P G T P G D P A R P P A S K A V P T F
50100150200250300SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q7Z7A3-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q7Z7A3-F1.cif  
DSSP Secondary Structures   Q7Z7A3.dssp  





Publications: