Modomics - A Database of RNA Modifications

ID Card:

Full name: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Synonym: JM23 CDLIV SPB1 TRM7 TRMT7
GI: 12643879
UniProt: Q9UET6
Alpha Fold Predicted Structure: AF-Q9UET6-F1
Enzyme type: methyltransferase



Protein sequence:

MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDPDFNQLDGPTRIIVPFVTCGDLSSYDSDRSYPLDLEGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAKEIRPQDCPISRVDTFPQPLAAPQCHTLLAPEMEDNEMSCSP

Comments:




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
N:Nm undefined RNA ()  

Alpha Fold Predicted Structure:






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Protein sequence:

M G R T S K D K R D V Y Y R L A K E N G W R A R S A F K L L Q L D K E F Q L F Q G V T R A V D L C A A P G S W S Q V L S Q K I G G Q G S G H V V A V D L Q A M A P L P G V V Q I Q G D I T Q L S T A K E I I Q H F K G C P A D L V V C D G A P D V T G L H D V D E Y M Q A Q L L L A A L N I A T H V L K P G G C F V A K I F R G R D V T L L Y S Q L Q V F F S S V L C A K P R S S R N S S I E A F A V C Q G Y D P P E G F I P D L S K P L L D H S Y D P D F N Q L D G P T R I I V P F V T C G D L S S Y D S D R S Y P L D L E G G S E Y K Y T P P T Q P P I S P P Y Q E A C T L K R K G Q L A K E I R P Q D C P I S R V D T F P Q P L A A P Q C H T L L A P E M E D N E M S C S P

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9UET6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9UET6-F1.cif  
DSSP Secondary Structures   Q9UET6.dssp  





Diseases connected to this enzyme:

Description Reaction Disease Name
2’-O-methylation of tRNAPhe may impact the development. N:Nm
Nonsyndromic X-Linked Intellectual Disability

Publications:

Title Authors Journal Details PubMed Id DOI
A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9). Ramser J, Winnepenninckx B, Lenski C, Errijgers V, Platzer M, Schwartz CE, Meindl A, Kooy RF... J Med Genet [details] 15342698 -
Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. Freude K, Hoffmann K, Jensen LR, Delatycki MB, des Portes V, Moser B, Hamel B, van Bokhoven H, Moraine C, Fryns JP, Chelly J, Gecz J, Lenzner S, Kalscheuer VM, Ropers HH... Am J Hum Genet [details] 15162322 -