ID Card:
Full name:
tRNA 2-selenouridine(34) synthase
Synonym:
SelU, YbbB
GI:
2506609
Orf:
ybbB, b0503
COG:
COG2603
UniProt:
P33667
Alpha Fold Predicted Structure:
AF-P33667-F1
Enzyme type:
selenotransferase/geranyltransferase
Position of modification - modification:
t :34 - mnm5se2U t :34 - mnm5ges2U t :34 - cmnm5ges2U
Protein sequence:
MQERHTEQDYRALLIADTPIIDVRAPIEFEHGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTAIQATIELAQKPIVLIGGCTGSGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLTTGSTDGHLAWLVPLLEEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR
Comments:
ybbB is a gene that is frequently found within bacterial operons that contain SelD, the selenophosphate synthetase gene, suggesting a role in selenium metabolism. ybbB is required in vivo for the specific substitution of selenium for sulfur in 2-thiouridine residues in E.coli tRNAs (Wolfe et al. 2004 ). ybbB directly catalyses the geranylation of E.coli tRNAs that contain (c)mnm5s2U (Dumelin et al. 2012 )
Alpha Fold Predicted Structure:
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Protein sequence:
M
Q
E
R
H
T
E
Q
D
Y
R
A
L
L
I
A
D
T
P
I
I
D
V
R
A
P
I
E
F
E
H
G
A
M
P
A
A
I
N
L
P
L
M
N
N
D
E
R
A
A
V
G
T
C
Y
K
Q
Q
G
S
D
A
A
L
A
L
G
H
K
L
V
A
G
E
I
R
Q
Q
R
M
D
A
W
R
A
A
C
L
Q
N
P
Q
G
I
L
C
C
A
R
G
G
Q
R
S
H
I
V
Q
S
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A
A
G
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Y
P
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G
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A
L
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T
A
I
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A
T
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A
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I
V
L
I
G
G
C
T
G
S
G
K
T
L
L
V
Q
Q
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P
N
G
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G
L
A
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A
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S
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N
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G
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G
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Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase.
Wolfe MD, Ahmed F, Lacourciere GM, Lauhon CT, Stadtman TC, Larson TJ
J Biol Chem
[details]
14594807
-
Discovery and biological characterization of geranylated RNA in bacteria.
Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR...
Nat Chem Biol
[details]
22983156
-
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