ID Card:
Full name:
CDK5 regulatory subunit associated protein 1 like 1/Threonylcarbamoyladenosine tRNA methylthiotransferase
Synonym:
FLJ20342
GI:
74747199
UniProt:
Q5VV42
Alpha Fold Predicted Structure:
AF-Q5VV42-F1
Enzyme type:
threonylcarbamoyladenosine synthetase
Protein sequence:
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Comments:
Threonylcarbamoyladenosine tRNA methylthiotransferase is a member of the methylthiontransferase family. Given the similarity with its mouse ortohologue Q91WE6 it is suggested that it catalyses the methylthionation of N6-threonyl-carbamoyl adenosine (t(6) A) leading to the formation of 2-methylthio-N6-threonyl-carbamoyl adenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenosine (ANN).
Alpha Fold Predicted Structure:
Clear Selection and Reset Camera
Clear Selection
Reset Camera
Protein sequence:
M
P
S
A
S
C
D
T
L
L
D
D
I
E
D
I
V
S
Q
E
D
S
K
P
Q
D
R
H
F
V
R
K
D
V
V
P
K
V
R
R
R
N
T
Q
K
Y
L
Q
E
E
E
N
S
P
P
S
D
S
T
I
P
G
I
Q
K
I
W
I
R
T
W
G
C
S
H
N
N
S
D
G
E
Y
M
A
G
Q
L
A
A
Y
G
Y
K
I
T
E
N
A
S
D
A
D
L
W
L
L
N
S
C
T
V
K
N
P
A
E
D
H
F
R
N
S
I
K
K
A
Q
E
E
N
K
K
I
V
L
A
G
C
V
P
Q
A
Q
P
R
Q
D
Y
L
K
G
L
S
I
I
G
V
Q
Q
I
D
R
V
V
E
V
V
E
E
T
I
K
G
H
S
V
R
L
L
G
Q
K
K
D
N
G
R
R
L
G
G
A
R
L
D
L
P
K
I
R
K
N
P
L
I
E
I
I
S
I
N
T
G
C
L
N
A
C
T
Y
C
K
T
K
H
A
R
G
N
L
A
S
Y
P
I
D
E
L
V
D
R
A
K
Q
S
F
Q
E
G
V
C
E
I
W
L
T
S
E
D
T
G
A
Y
G
R
D
I
G
T
N
L
P
T
L
L
W
K
L
V
E
V
I
P
E
G
A
M
L
R
L
G
M
T
N
P
P
Y
I
L
E
H
L
E
E
M
A
K
I
L
N
H
P
R
V
Y
A
F
L
H
I
P
V
Q
S
A
S
D
S
V
L
M
E
M
K
R
E
Y
C
V
A
D
F
K
R
V
V
D
F
L
K
E
K
V
P
G
I
T
I
A
T
D
I
I
C
G
F
P
G
E
T
D
Q
D
F
Q
E
T
V
K
L
V
E
E
Y
K
F
P
S
L
F
I
N
Q
F
Y
P
R
P
G
T
P
A
A
K
M
E
Q
V
P
A
Q
V
K
K
Q
R
T
K
D
L
S
R
V
F
H
S
Y
S
P
Y
D
H
K
I
G
E
R
Q
Q
V
L
V
T
E
E
S
F
D
S
K
F
Y
V
A
H
N
Q
F
Y
E
Q
V
L
V
P
K
N
P
A
F
M
G
K
M
V
E
V
D
I
Y
E
S
G
K
H
F
M
K
G
Q
P
V
S
D
A
K
V
Y
T
P
S
I
S
K
P
L
A
K
G
E
V
S
G
L
T
K
D
F
R
N
G
L
G
N
Q
L
S
S
G
S
H
T
S
A
A
S
Q
C
D
S
A
S
S
R
M
V
L
P
M
P
R
L
H
Q
D
C
A
L
R
M
S
V
G
L
A
L
L
G
L
L
F
A
F
F
V
K
V
Y
N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI