Modomics - A Database of RNA Modifications

ID Card:

Full name: TP53RK binding protein
Synonym: CGI-121 CGI121
GI: 74735252
UniProt: Q9Y3C4
Structures: | 3ENP | 6WQX |
Alpha Fold Predicted Structure: AF-Q9Y3C4-F1


PDB Structures:


3ENP

Structure Description:

Title: Crystal structure of human cgi121
Classification: HYDROLASE
Technique: X-Ray Diffraction
Resolution: 2.48
R value free: 0.257
R value observed: 0.213
R value work: 0.211

Abstract of the PDB Structure's related Publication:

Kae1 is a universally conserved ATPase and part of the essential gene set in bacteria. In archaea and eukaryotes, Kae1 is embedded within the protein kinase-containing KEOPS complex. Mutation of KEOPS subunits in yeast leads to striking telomere and transcription defects, but the exact biochemical function of KEOPS is not known. As a first step to elucidating its function, we solved the atomic structure of archaea-derived KEOPS complexes involving Kae1, Bud32, Pcc1, and Cgi121 subunits. Our studies suggest that Kae1 is regulated at two levels by the primordial protein kinase Bud32, which is itself regulated by Cgi121. Moreover, Pcc1 appears to function as a dimerization module, perhaps suggesting that KEOPS may be a processive molecular machine. Lastly, as Bud32 lacks the conventional substrate-recognition infrastructure of eukaryotic protein kinases including an activation segment, Bud32 may provide a glimpse of the evolutionary history of the protein kinase family.

Download RCSB-PDB Structures:

Pdb Files   3ENP.pdb   6WQX.pdb  
Pdbx/mmCIF Files   3ENP.cif   6WQX.cif  


Protein sequence:

MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL

Comments:





Alpha Fold Predicted Structure:




Parsing response... [166915/166915]


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Protein sequence:

M Q L T H Q L D L F P E C R V T L L L F K D V K N A G D L R R K A M E G T I D G S L I N P T V I V D P F Q I L V A A N K A V H L Y K L G K M K T R T L S T E I I F N L S P N N N I S E A L K K F G I S A N D T S I L I V Y I E E G E K Q I N Q E Y L I S Q V E G H Q V S L K N L P E I M N I T E V K K I Y K L S S Q E E S I G T L L D A I I C R M S T K D V L
20406080100120140160MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVLSequenceGHTBSN

Enter the variants

Position

Original

Variant

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9Y3C4-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9Y3C4-F1.cif  
DSSP Secondary Structures   Q9Y3C4.dssp  





Publications: