Modomics - A Database of RNA Modifications

Full name: tRNA (guanine-N(7)-)-methyltransferase
GI: 32171782
Orf: YDL201W
COG: COG0220
UniProt: Q12009
Structures: | 2VDU | 2VDV |
Complex: Trm8/Trm82
Enzyme type: methyltransferase
Position of modification - modification: t:46 - m7G


AdoMet is the methyl group donor. Heterodimer composed of two unrelated subunits: Trm8p (catalytic subunit) and Trm82p (cofactor, stimulates the activity of Trm8p, but is NOT absolutely essential). Works with Trm82p. Trm8p/Trm82p are not structuraly related. Belongs to the methyltransferase superfamily. TrmB family.

Protein sequence:


Enzymatic activities:

Reaction Substrate Type Position
G:m7G tRNA (t) Cys/GCA/prokaryotic cytosol 46
G:m7G tRNA (t) Ile/UAU/prokaryotic cytosol 46
G:m7G tRNA (t) Lys/CUU/prokaryotic cytosol 46
G:m7G tRNA (t) Lys/SUU/prokaryotic cytosol 46
G:m7G tRNA (t) Met/CAU/prokaryotic cytosol 46
G:m7G tRNA (t) Phe/GAA/prokaryotic cytosol 46
G:m7G tRNA (t) Pro/UGG/prokaryotic cytosol 46
G:m7G tRNA (t) Trp/CCA/prokaryotic cytosol 46
G:m7G tRNA (t) Val/CAC/prokaryotic cytosol 46
G:m7G tRNA (t) Val/IAC/prokaryotic cytosol 46
G:m7G tRNA (t)   46


Title Authors Journal Details PubMed Id DOI
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. Alexandrov A, Martzen MR, Phizicky EM RNA [details] 12403464 -
Structure of the yeast tRNA m7G methylation complex. Leulliot N, Chaillet M, Durand D, Ulryck N, Blondeau K, van Tilbeurgh H Structure [details] 18184583 -

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