Modomics - A Database of RNA Modifications

Full name:	nucleophosmin 1
Synonym:	B23,NPM
GI:	None
Orf:	None
COG:	None
UniProt:	P06748
Structures:	\| 2llh \|
Complex:	None

Comments:

None

Protein sequence:

MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVL
RLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTP
AKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL

Diseases connected to this enzyme:

Description	Reaction	Disease Name
2′-O-Me-regulated translation is important for cellular growth, differentiation, and hematopoietic stem cell maintenance. Aberrant 2'O-Me is induced by mutations in NPM1 observed in patients with dyskeratosis congenita.	xX:Xm	Dyskeratosis Congenita