ID Card:
Full name:
(2'-O-methyladenosine-N(6)-)-methyltransferase
Synonym:
C20orf67, CAPAM, PPP1R121
GI:
27348125
Orf:
C20orf67
UniProt:
Q9H4Z3
Structures:
|
2JX8 |
6IRV |
6IRW |
Alpha Fold Predicted Structure:
AF-Q9H4Z3-F1
Complex:
None
Enzyme type:
methyltransferase
PDB Structures:
2JX8
6IRV
6IRW
}
2JX8
Structure Description:
Title:
Solution structure of hPCIF1 WW domain
Classification:
TRANSCRIPTION
NMR Solution
50
20
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT
Comments:
Cap-specific adenosine methyltransferase that catalyzes formation of N6,2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the first transcribed position of capped mRNAs.
Alpha Fold Predicted Structure:
Parsing response... [646383/646383]
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Protein sequence:
M
A
N
E
N
H
G
S
P
R
E
E
A
S
L
L
S
H
S
P
G
T
S
N
Q
S
Q
P
C
S
P
K
P
I
R
L
V
Q
D
L
P
E
E
L
V
H
A
G
W
E
K
C
W
S
R
R
E
N
R
P
Y
Y
F
N
R
F
T
N
Q
S
L
W
E
M
P
V
L
G
Q
H
D
V
I
S
D
P
L
G
L
N
A
T
P
L
P
Q
D
S
S
L
V
E
T
P
P
A
E
N
K
P
R
K
R
Q
L
S
E
E
Q
P
S
G
N
G
V
K
K
P
K
I
E
I
P
V
T
P
T
G
Q
S
V
P
S
S
P
S
I
P
G
T
P
T
L
K
M
W
G
T
S
P
E
D
K
Q
Q
A
A
L
L
R
P
T
E
V
Y
W
D
L
D
I
Q
T
N
A
V
I
K
H
R
G
P
S
E
V
L
P
P
H
P
E
V
E
L
L
R
S
Q
L
I
L
K
L
R
Q
H
Y
R
E
L
C
Q
Q
R
E
G
I
E
P
P
R
E
S
F
N
R
W
M
L
E
R
K
V
V
D
K
G
S
D
P
L
L
P
S
N
C
E
P
V
V
S
P
S
M
F
R
E
I
M
N
D
I
P
I
R
L
S
R
I
K
F
R
E
E
A
K
R
L
L
F
K
Y
A
E
A
A
R
R
L
I
E
S
R
S
A
S
P
D
S
R
K
V
V
K
W
N
V
E
D
T
F
S
W
L
R
K
D
H
S
A
S
K
E
D
Y
M
D
R
L
E
H
L
R
R
Q
C
G
P
H
V
S
A
A
A
K
D
S
V
E
G
I
C
S
K
I
Y
H
I
S
L
E
Y
V
K
R
I
R
E
K
H
L
A
I
L
K
E
N
N
I
S
E
E
V
E
A
P
E
V
E
P
R
L
V
Y
C
Y
P
V
R
L
A
V
S
A
P
P
M
P
S
V
E
M
H
M
E
N
N
V
V
C
I
R
Y
K
G
E
M
V
K
V
S
R
N
Y
F
S
K
L
W
L
L
Y
R
Y
S
C
I
D
D
S
A
F
E
R
F
L
P
R
V
W
C
L
L
R
R
Y
Q
M
M
F
G
V
G
L
Y
E
G
T
G
L
Q
G
S
L
P
V
H
V
F
E
A
L
H
R
L
F
G
V
S
F
E
C
F
A
S
P
L
N
C
Y
F
R
Q
Y
C
S
A
F
P
D
T
D
G
Y
F
G
S
R
G
P
C
L
D
F
A
P
L
S
G
S
F
E
A
N
P
P
F
C
E
E
L
M
D
A
M
V
S
H
F
E
R
L
L
E
S
S
P
E
P
L
S
F
I
V
F
I
P
E
W
R
E
P
P
T
P
A
L
T
R
M
E
Q
S
R
F
K
R
H
Q
L
I
L
P
A
F
E
H
E
Y
R
S
G
S
Q
H
I
C
K
K
E
E
M
H
Y
K
A
V
H
N
T
A
V
L
F
L
Q
N
D
P
G
F
A
K
W
A
P
T
P
E
R
L
Q
E
L
S
A
A
Y
R
Q
S
G
R
S
H
S
S
G
S
S
S
S
S
S
S
E
A
K
D
R
D
S
G
R
E
Q
G
P
S
R
E
P
H
P
T
100 200 300 400 500 600 700 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: