Modomics - A Database of RNA Modifications

ID Card:

Full name: (2'-O-methyladenosine-N(6)-)-methyltransferase
Synonym: C20orf67, CAPAM, PPP1R121
GI: 27348125
Orf: C20orf67
UniProt: Q9H4Z3
Structures: | 2JX8 | 6IRV | 6IRW |
Alpha Fold Predicted Structure: AF-Q9H4Z3-F1
Complex: None
Enzyme type: methyltransferase


PDB Structures:


2JX8

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   2JX8.pdb   6IRV.pdb   6IRW.pdb   7BGB.pdb   7TRC.pdb   7V9A.pdb  
Pdbx/mmCIF Files   2JX8.cif   6IRV.cif   6IRW.cif   7BGB.cif   7TRC.cif   7V9A.cif  


Protein sequence:

MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT

Comments:

Cap-specific adenosine methyltransferase that catalyzes formation of N6,2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the first transcribed position of capped mRNAs.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A N E N H G S P R E E A S L L S H S P G T S N Q S Q P C S P K P I R L V Q D L P E E L V H A G W E K C W S R R E N R P Y Y F N R F T N Q S L W E M P V L G Q H D V I S D P L G L N A T P L P Q D S S L V E T P P A E N K P R K R Q L S E E Q P S G N G V K K P K I E I P V T P T G Q S V P S S P S I P G T P T L K M W G T S P E D K Q Q A A L L R P T E V Y W D L D I Q T N A V I K H R G P S E V L P P H P E V E L L R S Q L I L K L R Q H Y R E L C Q Q R E G I E P P R E S F N R W M L E R K V V D K G S D P L L P S N C E P V V S P S M F R E I M N D I P I R L S R I K F R E E A K R L L F K Y A E A A R R L I E S R S A S P D S R K V V K W N V E D T F S W L R K D H S A S K E D Y M D R L E H L R R Q C G P H V S A A A K D S V E G I C S K I Y H I S L E Y V K R I R E K H L A I L K E N N I S E E V E A P E V E P R L V Y C Y P V R L A V S A P P M P S V E M H M E N N V V C I R Y K G E M V K V S R N Y F S K L W L L Y R Y S C I D D S A F E R F L P R V W C L L R R Y Q M M F G V G L Y E G T G L Q G S L P V H V F E A L H R L F G V S F E C F A S P L N C Y F R Q Y C S A F P D T D G Y F G S R G P C L D F A P L S G S F E A N P P F C E E L M D A M V S H F E R L L E S S P E P L S F I V F I P E W R E P P T P A L T R M E Q S R F K R H Q L I L P A F E H E Y R S G S Q H I C K K E E M H Y K A V H N T A V L F L Q N D P G F A K W A P T P E R L Q E L S A A Y R Q S G R S H S S G S S S S S S S E A K D R D S G R E Q G P S R E P H P T

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9H4Z3-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9H4Z3-F1.cif  
DSSP Secondary Structures   Q9H4Z3.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Cap-specific terminal -methylation of RNA by an RNA polymerase II-associated methyltransferase. Shinichiro Akichika,Seiichi Hirano,Yuichi Shichino,Takeo Suzuki,Hiroshi Nishimasu,Ryuichiro Ishitani,Ai Sugita,Yutaka Hirose,Shintaro Iwasaki,Osamu Nureki,Tsutomu Suzuki Science [details] 30467178 -
Cap-specific, terminal N-methylation by a mammalian mAm methyltransferase. Hanxiao Sun,Meiling Zhang,Kai Li,Dongsheng Bai,Chengqi Yi Cell Res [details] 30487554 -
Identification of the mAm Methyltransferase PCIF1 Reveals the Location and Functions of mAm in the Transcriptome. Konstantinos Boulias,Diana Toczydłowska-Socha,Ben R Hawley,Noa Liberman,Ken Takashima,Sara Zaccara,Théo Guez,Jean-Jacques Vasseur,Françoise Debart,L Aravind,Samie R Jaffrey,Eric Lieberman Greer Mol Cell [details] 31279658 -
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Erdem Sendinc,David Valle-Garcia,Abhinav Dhall,Hao Chen,Telmo Henriques,Jose Navarrete-Perea,Wanqiang Sheng,Steven P Gygi,Karen Adelman,Yang Shi Mol Cell [details] 31279659 -