Modomics - A Database of RNA Modifications

ID Card:

Full name: N(6)-adenine-specific methyltransferase
GI: 269849669
UniProt: Q8N3J2
Alpha Fold Predicted Structure: AF-Q8N3J2-F1
Enzyme type: methyltransferase



Protein sequence:

MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCAAFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNGVKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFEKQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVENNSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNRYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS

Comments:

N6-adenine-specific RNA methyltransferase catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M S V V H Q L S A G W L L D H L S F I N K I N Y Q L H Q H H E P C C R K K E F T T S V H F E S L Q M D S V S S S G V C A A F I A S D S S T K P E N D D G G N Y E M F T R K F V F R P E L F D V T K P Y I T P A V H K E C Q Q S N E K E D L M N G V K K E I S I S I I G K K R K R C V V F N Q G E L D A M E Y H T K I R E L I L D G S L Q L I Q E G L K S G F L Y P L F E K Q D K G S K P I T L P L D A C S L S E L C E M A K H L P S L N E M E H Q T L Q L V E E D T S V T E Q D L F L R V V E N N S S F T K V I T L M G Q K Y L L P P K S S F L L S D I S C M Q P L L N Y R K T F D V I V I D P P W Q N K S V K R S N R Y S Y L S P L Q I Q Q I P I P K L A A P N C L L V T W V T N R Q K H L R F I K E E L Y P S W S V E V V A E W H W V K I T N S G E F V F P L D S P H K K P Y E G L I L G R V Q E K T A L P L R N A D V N V L P I P D H K L I V S V P C T L H S H K P P L A E V L K D Y I K P D G E Y L E L F A R N L Q P G W T S W G N E V L K F Q H V D Y F I A V E S G S

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8N3J2-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8N3J2-F1.cif  
DSSP Secondary Structures   Q8N3J2.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
METTL4 is an snRNA mAm methyltransferase that regulates RNA splicing. Hao Chen,Lei Gu,Esteban A Orellana,Yuanyuan Wang,Jiaojiao Guo,Qi Liu,Longfei Wang,Zhangfei Shen,Hao Wu,Richard I Gregory,Yi Xing,Yang Shi Cell Res [details] 31913360 -
N-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. Ziyang Hao,Tong Wu,Xiaolong Cui,Pingping Zhu,Caiping Tan,Xiaoyang Dou,Kai-Wen Hsu,Yueh-Te Lin,Pei-Hua Peng,Li-Sheng Zhang,Yawei Gao,Lulu Hu,Hui-Lung Sun,Allen Zhu,Jianzhao Liu,Kou-Juey Wu,Chuan He Mol Cell [details] 32183942 -