ID Card:
Full name:
N(6)-adenine-specific methyltransferase
GI:
269849669
UniProt:
Q8N3J2
Alpha Fold Predicted Structure:
AF-Q8N3J2-F1
Enzyme type:
methyltransferase
Protein sequence:
MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCAAFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNGVKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFEKQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVENNSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNRYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS
Comments:
N6-adenine-specific RNA methyltransferase catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
V
V
H
Q
L
S
A
G
W
L
L
D
H
L
S
F
I
N
K
I
N
Y
Q
L
H
Q
H
H
E
P
C
C
R
K
K
E
F
T
T
S
V
H
F
E
S
L
Q
M
D
S
V
S
S
S
G
V
C
A
A
F
I
A
S
D
S
S
T
K
P
E
N
D
D
G
G
N
Y
E
M
F
T
R
K
F
V
F
R
P
E
L
F
D
V
T
K
P
Y
I
T
P
A
V
H
K
E
C
Q
Q
S
N
E
K
E
D
L
M
N
G
V
K
K
E
I
S
I
S
I
I
G
K
K
R
K
R
C
V
V
F
N
Q
G
E
L
D
A
M
E
Y
H
T
K
I
R
E
L
I
L
D
G
S
L
Q
L
I
Q
E
G
L
K
S
G
F
L
Y
P
L
F
E
K
Q
D
K
G
S
K
P
I
T
L
P
L
D
A
C
S
L
S
E
L
C
E
M
A
K
H
L
P
S
L
N
E
M
E
H
Q
T
L
Q
L
V
E
E
D
T
S
V
T
E
Q
D
L
F
L
R
V
V
E
N
N
S
S
F
T
K
V
I
T
L
M
G
Q
K
Y
L
L
P
P
K
S
S
F
L
L
S
D
I
S
C
M
Q
P
L
L
N
Y
R
K
T
F
D
V
I
V
I
D
P
P
W
Q
N
K
S
V
K
R
S
N
R
Y
S
Y
L
S
P
L
Q
I
Q
Q
I
P
I
P
K
L
A
A
P
N
C
L
L
V
T
W
V
T
N
R
Q
K
H
L
R
F
I
K
E
E
L
Y
P
S
W
S
V
E
V
V
A
E
W
H
W
V
K
I
T
N
S
G
E
F
V
F
P
L
D
S
P
H
K
K
P
Y
E
G
L
I
L
G
R
V
Q
E
K
T
A
L
P
L
R
N
A
D
V
N
V
L
P
I
P
D
H
K
L
I
V
S
V
P
C
T
L
H
S
H
K
P
P
L
A
E
V
L
K
D
Y
I
K
P
D
G
E
Y
L
E
L
F
A
R
N
L
Q
P
G
W
T
S
W
G
N
E
V
L
K
F
Q
H
V
D
Y
F
I
A
V
E
S
G
S
50 100 150 200 250 300 350 400 450 Sequence G H I T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: