Modomics - A Database of RNA Modifications

Full name:	N6-adenosine-methyltransferase non-catalytic subunit MTB
Synonym:	Methyltransferase-like protein 1, Protein EMBRYO DEFECTIVE 1691, Protein METTL14 homolog
GI:	None
Orf:
COG:
UniProt:	Q94AI4
Structures:	\| \|
Complex:	MTA

Comments:

Probable non-catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences

Protein sequence:

MKKKQEESSLEKLSTWYQDGEQDGGDRSEKRRMSLKASDFESSSRSGGSKSKEDNKSVVDVEHQDRDSKRERDGRERTHGSSSDSSKRKRWDEAGGLVND
GDHKSSKLSDSRHDSGGERVSVSNEHGESRRDLKSDRSLKTSSRDEKSKSRGVKDDDRGSPLKKTSGKDGSEVVREVGRSNRSKTPDADYEKEKYSRKDE
RSRGRDDGWSDRDRDQEGLKDNWKRRHSSSGDKDQKDGDLLYDRGREREFPRQGRERSEGERSHGRLGGRKDGNRGEAVKALSSGGVSNENYDVIEIQTK
PHDYVRGESGPNFARMTESGQQPPKKPSNNEEEWAHNQEGRQRSETFGFGSYGEDSRDEAGEASSDYSGAKARNQRGSTPGRTNFVQTPNRGYQTPQGTR
GNRPLRGGKGRPAGGRENQQGAIPMPIMGSPFANLGMPPPSPIHSLTPGMSPIPGTSVTPVFMPPFAPTLIWPGARGVDGNMLPVPPVLSPLPPGPSGPR
FPSIGTPPNPNMFFTPPGSDRGGPPNFPGSNISGQMGRGMPSDKTSGGWVPPRGGGPPGKAPSRGEQNDYSQNFVDTGMRPQNFIRELELTNVEDYPKLR
ELIQKKDEIVSNSASAPMYLKGDLHEVELSPELFGTKFDVILVDPPWEEYVHRAPGVSDSMEYWTFEDIINLKIEAIADTPSFLFLWVGDGVGLEQGRQC
LKKWGFRRCEDICWVKTNKSNAAPTLRHDSRTVFQRSKEHCLMGIKGTVRRSTDGHIIHANIDTDVIIAEEPPYG

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.	Růžička K, Zhang M, Campilho A, Bodi Z, Kashif M, Saleh M, Eeckhout D, El-Showk S, Li H, Zhong S, De Jaeger G, Mongan NP, Hejátko J, Helariutta Y, Fray RG	New Phytol.	[details]	28503769	10.1111/nph.14586