Modomics - A Database of RNA Modifications

ID Card:

Full name: Ribosomal RNA small subunit methyltransferase, mitochondrial
Synonym: 18S mitochondrial rRNA (adenine(1914)-N(6)/adenine(1915)-N(6))-dimethyltransferase, Adenosine dimethyl transferase 1B, Dimethyladenosine transferase 1B
GI: 75171146
UniProt: Q9FK02
Alpha Fold Predicted Structure: AF-Q9FK02-F1
Enzyme type: methyltransferase



Protein sequence:

MILRLKDQTLIKINSTRSYLSSLVFRRDSHSQARTKPDHDRRRRGYERDVRIEEKKEHDGLFLCKSKGQHLLTNTRILDSIVRSSDIRPTDTVLEIGPGTGNLTMKLLEAAQNVVAVELDKRMVEILRKRVSDHGFADKLTIIQKDVLKTDFPHFDLVVANIPYNISSPLVAKLVYGSNTFRSATLLLQKEFSRRLLANPGDSDFNRLAVNVKLVADVKFVMDVSKREFVPPPKVDSSVIRITPKEIIPDVNVQEWLAFTRTCFGKKNKTLGSMFRQKKKVMELQSLSAGRHGSNVEVMNQTGGDSDSDVEEDGKDDLLCLDTDASMFKERVIEILRTNGFEEKRPSKLSHRELLHLLSLFNQAGIFFHDITSLQMDLHE

Comments:

It is an S-adenosyl-L-methionine-dependent enzyme that mediates the dimethylation of two conserved adenosines near the 3'-end of the rRNA in the small ribosomal subunit of bacteria, archaea, and eukaryotes (Richter et al. 2010 ). Specifically, it mediates the methylation of the AA dinucleotide in the plant mitochondrial 18s rRNA, A|1914 and A|1915.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M I L R L K D Q T L I K I N S T R S Y L S S L V F R R D S H S Q A R T K P D H D R R R R G Y E R D V R I E E K K E H D G L F L C K S K G Q H L L T N T R I L D S I V R S S D I R P T D T V L E I G P G T G N L T M K L L E A A Q N V V A V E L D K R M V E I L R K R V S D H G F A D K L T I I Q K D V L K T D F P H F D L V V A N I P Y N I S S P L V A K L V Y G S N T F R S A T L L L Q K E F S R R L L A N P G D S D F N R L A V N V K L V A D V K F V M D V S K R E F V P P P K V D S S V I R I T P K E I I P D V N V Q E W L A F T R T C F G K K N K T L G S M F R Q K K K V M E L Q S L S A G R H G S N V E V M N Q T G G D S D S D V E E D G K D D L L C L D T D A S M F K E R V I E I L R T N G F E E K R P S K L S H R E L L H L L S L F N Q A G I F F H D I T S L Q M D L H E
50100150200250300350SequenceGHTSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9FK02-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9FK02-F1.cif  
DSSP Secondary Structures   Q9FK02.dssp  





Publications: