Modomics - A Database of RNA Modifications

Full name:	16S rRNA (guanine(1405)-N(7))-methyltransferase
Synonym:	16S rRNA m7G1405 methyltransferase
GI:	1035502231
Orf:
COG:
UniProt:	Q33DX5
Structures:	\| 6PQB \| 6CN0 \|
Complex:	none
Enzyme type:	methyltransferase
Position of modification - modification:

Comments:

Specifically methylates the N7 position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin and kanamycin.

Protein sequence:

MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLK
ILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLL
LMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms.	Jun-Ichi Wachino,Keigo Shibayama,Kouji Kimura,Kunikazu Yamane,Satowa Suzuki,Yoshichika Arakawa	FEMS Microbiol Lett	[details]	20722735	-
Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition.	Meisam Nosrati,Debayan Dey,Atousa Mehrani,Sarah E Strassler,Natalia Zelinskaya,Eric D Hoffer,Scott M Stagg,Christine M Dunham,Graeme L Conn	J Biol Chem	[details]	31594862	-