| Full name: |
rRNA adenine N-6-methyltransferase |
| Synonym: |
Erythromycin resistance protein, Macrolide-lincosamide-streptogramin B resistance protein |
| GI: |
None |
| Orf: |
|
| COG: |
|
| UniProt: |
P07287 |
| Structures: |
|
6NVM |
|
| Complex: |
none |
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
|
Comments:
The Erm methyltransferases confer resistance to macrolide, lincosamide and streptogramin B (MLS) antibiotics by methylation of a single adenosine base within bacterial 23 S ribosomal RNA. The ErmE methyltransferase, from the macrolide-producing bacterium Saccharopolyspora erythraea, recognizes a motif within domain V of the rRNA that specifically targets adenosine 2058 (A2058) for methylation.
Protein sequence:
MSSSDEQPRPRRRNQDRQHPNQNRPVLGRTERDRNRRQFGQNFLRDRKTIARIAETAELRPDLPVLEAGPGEGLLTRELADRARQVTSYEIDPRLAKSLR
EKLSGHPNIEVVNADFLTAEPPPEPFAFVGAIPYGITSAIVDWCLEAPTIETATMVTQLEFARKRTGDYGRWSRLTVMTWPLFEWEFVEKVDRRLFKPVP
KVDSAIMRLRRRAEPLLEGAALERYESMVELCFTGVGGNIQASLLRKYPRRRVEAALDHAGVGGGAVVAYVRPEQWLRLFERLDQKNEPRGGQPQRGRRT
GGRDHGDRRTGGQDRGDRRTGGRDHRDRQASGHGDRRSSGRNRDDGRTGEREQGDQGGRRGPSGGGRTGGRPGRRGGPGQR
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
Alena Stsiapanava,Maria Selmer |
Sci Rep |
[details]
|
31601908
|
-
|
| ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA. |
I D Villsen,B Vester,S Douthwaite |
J Mol Biol |
[details]
|
9973557
|
-
|
| Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase. |
B Vester,S Douthwaite |
J Bacteriol |
[details]
|
7961464
|
-
|
| The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase. |
B Vester,L H Hansen,S Douthwaite |
RNA |
[details]
|
7489511
|
-
|
Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact:
Andrea Cappannini - lp.vog.bcmii@ininnappaca