ID Card:
Full name:
tRNA (uracil(54)-C(5))-methyltransferase homolog
Synonym:
TRM2 homolog
GI:
74762656
UniProt:
Q96GJ1
Alpha Fold Predicted Structure:
AF-Q96GJ1-F1
Complex:
none
Enzyme type:
methyltransferase
Protein sequence:
MAGLKRRVPLHSLRYFISMVGLFSKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKCQKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQMLNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRDGNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTMAIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQSPYQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVLQQAVPVDLFPHTPHCELVLLFTR
Comments:
TRMT2B is responsible for both tRNA and rRNA m5U-methylation in human mitochondria. TRMT2B is not essential for viability in human cells. Knoc-out of the TRMT2B gene shows no obvious phenotype with regards to RNA stability, mitochondrial translation, or cellular growth.
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
G
L
K
R
R
V
P
L
H
S
L
R
Y
F
I
S
M
V
G
L
F
S
K
P
G
L
L
P
W
Y
A
R
N
P
P
G
W
S
Q
L
F
L
G
T
V
C
K
G
D
F
T
R
V
I
A
T
K
C
Q
K
G
Q
K
S
Q
K
K
P
S
H
L
G
P
L
D
G
S
W
Q
E
R
L
A
D
V
V
T
P
L
W
R
L
S
Y
E
E
Q
L
K
V
K
F
A
A
Q
K
K
I
L
Q
R
L
E
S
Y
I
Q
M
L
N
G
V
S
V
T
T
A
V
P
K
S
E
R
L
S
C
L
L
H
P
I
I
P
S
P
V
I
N
G
Y
R
N
K
S
T
F
S
V
N
R
G
P
D
G
N
P
K
T
V
G
F
Y
L
G
T
W
R
D
G
N
V
V
C
V
Q
S
N
H
L
K
N
I
P
E
K
H
S
Q
V
A
Q
Y
Y
E
V
F
L
R
Q
S
P
L
E
P
C
L
V
F
H
E
G
G
Y
W
R
E
L
T
V
R
T
N
S
Q
G
H
T
M
A
I
I
T
F
H
P
Q
K
L
S
Q
E
E
L
H
V
Q
K
E
I
V
K
E
F
F
I
R
G
P
G
A
A
C
G
L
T
S
L
Y
F
Q
E
S
T
M
T
R
C
S
H
Q
Q
S
P
Y
Q
L
L
F
G
E
P
Y
I
F
E
E
L
L
S
L
K
I
R
I
S
P
D
A
F
F
Q
I
N
T
A
G
A
E
M
L
Y
R
T
V
G
E
L
T
G
V
N
S
D
T
I
L
L
D
I
C
C
G
T
G
V
I
G
L
S
L
A
Q
H
T
S
R
V
L
G
I
E
L
L
E
Q
A
V
E
D
A
R
W
T
A
A
F
N
G
I
T
N
S
E
F
H
T
G
Q
A
E
K
I
L
P
G
L
L
K
S
K
E
D
G
Q
S
I
V
A
V
V
N
P
A
R
A
G
L
H
Y
K
V
I
Q
A
I
R
N
F
R
A
I
H
T
L
V
F
V
S
C
K
L
H
G
E
S
T
R
N
V
I
E
L
C
C
P
P
D
P
A
K
K
L
L
G
E
P
F
V
L
Q
Q
A
V
P
V
D
L
F
P
H
T
P
H
C
E
L
V
L
L
F
T
R
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for mU formation in both tRNA and rRNA.
Ivan Laptev,Ekaterina Shvetsova,Sergey Levitskii,Marina Serebryakova,Maria Rubtsova,Alexey Bogdanov,Piotr Kamenski,Petr Sergiev,Olga Dontsova
RNA Biol
[details]
31736397
-