Modomics - A Database of RNA Modifications

ID Card:

Full name: Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial
UniProt: P36056
Alpha Fold Predicted Structure: AF-P36056-F1
Enzyme type: methyltransferase



Protein sequence:

MMKRCFSILPQNVRFSSKFTSLNLPKLDLADFIDSNKRGINVLPSYRDETASTTQATNSKELRLLSKTLQGQSYRDQLELNPDVSKAINNNIMAVHIPNNLRRVATNYYKEIQEPNSLHRPCRTKMEVDAHIASIFLQNYGSIFQSLKELQKRVGPDNFKPQRILDVGYGPATGIVALNDILGPNYRPDLKDAVILGNAEMQERAKIILSRQLNEVVDTVEENVSTEKEQETDRRNKNFQEDEHIGEVMTKKINIMTNLRSSIPASKEYDLIILTHQLLHDGNQFPIQVDENIEHYLNILAPGGHIVIIERGNPMGFEIIARARQITLRPENFPDEFGKIPRPWSRGVTVRGKKDAELGNISSNYFLKVIAPCPHQRKCPLQVGNPNFYTHKEGKDLKFCNFQKSIKRPKFSIELKKGKLLATSWDGSQGNASRLKGTGRRNGRDYEILNYSYLIFERSHKDENTLKEIKKLRNENVNGKYDIGSLGDDTQNSWPRIINDPVKRKGHVMMDLCAPSGELEKWTVSRSFSKQIYHDARKSKKGDLWASAAKTQIKGLGDLNVKKFHKLEKERIKQLKKEERQKARKAMESYNELEDSLQFDDHQFSNFEVMKKLSTFHGNDFLQHVNRK

Comments:

Monomeric variant of Rsm22 methylates mitochondrial tRNAs in vitro. Physiological RNA substrate not known yet.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M M K R C F S I L P Q N V R F S S K F T S L N L P K L D L A D F I D S N K R G I N V L P S Y R D E T A S T T Q A T N S K E L R L L S K T L Q G Q S Y R D Q L E L N P D V S K A I N N N I M A V H I P N N L R R V A T N Y Y K E I Q E P N S L H R P C R T K M E V D A H I A S I F L Q N Y G S I F Q S L K E L Q K R V G P D N F K P Q R I L D V G Y G P A T G I V A L N D I L G P N Y R P D L K D A V I L G N A E M Q E R A K I I L S R Q L N E V V D T V E E N V S T E K E Q E T D R R N K N F Q E D E H I G E V M T K K I N I M T N L R S S I P A S K E Y D L I I L T H Q L L H D G N Q F P I Q V D E N I E H Y L N I L A P G G H I V I I E R G N P M G F E I I A R A R Q I T L R P E N F P D E F G K I P R P W S R G V T V R G K K D A E L G N I S S N Y F L K V I A P C P H Q R K C P L Q V G N P N F Y T H K E G K D L K F C N F Q K S I K R P K F S I E L K K G K L L A T S W D G S Q G N A S R L K G T G R R N G R D Y E I L N Y S Y L I F E R S H K D E N T L K E I K K L R N E N V N G K Y D I G S L G D D T Q N S W P R I I N D P V K R K G H V M M D L C A P S G E L E K W T V S R S F S K Q I Y H D A R K S K K G D L W A S A A K T Q I K G L G D L N V K K F H K L E K E R I K Q L K K E E R Q K A R K A M E S Y N E L E D S L Q F D D H Q F S N F E V M K K L S T F H G N D F L Q H V N R K

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P36056-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P36056-F1.cif  
DSSP Secondary Structures   P36056.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae. Jahangir Alam,Farah Tazkera Rahman,Shiv K Sah-Teli,Rajaram Venkatesan,M Kristian Koski,Kaija J Autio,J Kalervo Hiltunen,Alexander J Kastaniotis Acta Crystallogr D Struct Biol [details] 34076597 -