Modomics - A Database of RNA Modifications

ID Card:

Full name: mitochondrial tRNA N(3)-methylcytidine methyltransferase, mRNA N(3)-methylcytidine methyltransferase
GI: 160410001
UniProt: Q9H825
Alpha Fold Predicted Structure: AF-Q9H825-F1
Enzyme type: methyltransferase



Protein sequence:

MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI

Comments:

S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of mRNAs and tRNA.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M N M I W R N S I S C L R L G K V P H R Y Q S G Y H P V A P L G S R I L T D P A K V F E H N M W D H M Q W S K E E E A A A R K K V K E N S A V R V L L E E Q V K Y E R E A S K Y W D T F Y K I H K N K F F K D R N W L L R E F P E I L P V D Q K P E E K A R E S S W D H V K T S A T N R F S R M H C P T V P D E K N H Y E K S S G S S E G Q S K T E S D F S N L D S E K H K K G P M E T G L F P G S N A T F R I L E V G C G A G N S V F P I L N T L E N S P E S F L Y C C D F A S G A V E L V K S H S S Y R A T Q C F A F V H D V C D D G L P Y P F P D G I L D V I L L V F V L S S I H P D R T L F I

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9H825-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9H825-F1.cif  
DSSP Secondary Structures   Q9H825.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, Liu X, Sheng N, Oo KS, Liang J, Chionh YH, Xu J, Ye F, Gao YG, Dedon PC, Fu XY J Biol Chem [details] 28655767 10.1074/jbc.M117.798298