Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA N(3)-methylcytidine methyltransferase
GI: 317373413
UniProt: Q6P1Q9
Alpha Fold Predicted Structure: AF-Q6P1Q9-F1
Complex: DALRD3 (for tRNA Arg substrate)
Enzyme type: methyltransferase



Protein sequence:

MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS

Comments:

METTL2B (similarly to METTL2A) mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). The activity of METTL2 towards tRNA substrates is reduced to 1/10 in comparison to METTL2A. METTL2B protein carries 6 single amino acid substitutions comparing to METTL2A (V12I, R26S, P124C, L155P, I266V, M288V).





Alpha Fold Predicted Structure:




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Protein sequence:

M A G S Y P E G A P A I L A D K R Q Q F G S R F L S D P A R V F H H N A W D N V E W S E E Q A A A A E R K V Q E N S I Q R V C Q E K Q V D Y E I N A H K Y W N D F Y K I H E N G F F K D R H W L F T E F P E L A P S Q N Q N H L K D W F L E N K S E V C E C R N N E D G P G L I M E E Q H K C S S K S L E H K T Q T P P V E E N V T Q K I S D L E I C A D E F P G S S A T Y R I L E V G C G V G N T V F P I L Q T N N D P G L F V Y C C D F S S T A I E L V Q T N S E Y D P S R C F A F V H D L C D E E K S Y P V P K G S L D I I I L I F V L S A V V P D K M Q K A I N R L S R L L K P G G M V L L R D Y G R Y D M A Q L R F K K G Q C L S G N F Y V R G D G T R V Y F F T Q E E L D T L F T T A G L E K V Q N L V D R R L Q V N R G K Q L T M Y R V W I Q C K Y C K P L L S S T S
50100150200250300350SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q6P1Q9-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q6P1Q9-F1.cif  
DSSP Secondary Structures   Q6P1Q9.dssp  





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