ID Card:
Full name:
tRNA N(3)-methylcytidine methyltransferase
GI:
317373413
UniProt:
Q6P1Q9
Alpha Fold Predicted Structure:
AF-Q6P1Q9-F1
Complex:
DALRD3 (for tRNA Arg substrate)
Enzyme type:
methyltransferase
Protein sequence:
MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
Comments:
METTL2B (similarly to METTL2A) mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). The activity of METTL2 towards tRNA substrates is reduced to 1/10 in comparison to METTL2A. METTL2B protein carries 6 single amino acid substitutions comparing to METTL2A (V12I, R26S, P124C, L155P, I266V, M288V).
Alpha Fold Predicted Structure:
Downloading... [89850/354784]
Clear Selection and Reset Camera
Clear Selection
Reset Camera
Protein sequence:
M
A
G
S
Y
P
E
G
A
P
A
I
L
A
D
K
R
Q
Q
F
G
S
R
F
L
S
D
P
A
R
V
F
H
H
N
A
W
D
N
V
E
W
S
E
E
Q
A
A
A
A
E
R
K
V
Q
E
N
S
I
Q
R
V
C
Q
E
K
Q
V
D
Y
E
I
N
A
H
K
Y
W
N
D
F
Y
K
I
H
E
N
G
F
F
K
D
R
H
W
L
F
T
E
F
P
E
L
A
P
S
Q
N
Q
N
H
L
K
D
W
F
L
E
N
K
S
E
V
C
E
C
R
N
N
E
D
G
P
G
L
I
M
E
E
Q
H
K
C
S
S
K
S
L
E
H
K
T
Q
T
P
P
V
E
E
N
V
T
Q
K
I
S
D
L
E
I
C
A
D
E
F
P
G
S
S
A
T
Y
R
I
L
E
V
G
C
G
V
G
N
T
V
F
P
I
L
Q
T
N
N
D
P
G
L
F
V
Y
C
C
D
F
S
S
T
A
I
E
L
V
Q
T
N
S
E
Y
D
P
S
R
C
F
A
F
V
H
D
L
C
D
E
E
K
S
Y
P
V
P
K
G
S
L
D
I
I
I
L
I
F
V
L
S
A
V
V
P
D
K
M
Q
K
A
I
N
R
L
S
R
L
L
K
P
G
G
M
V
L
L
R
D
Y
G
R
Y
D
M
A
Q
L
R
F
K
K
G
Q
C
L
S
G
N
F
Y
V
R
G
D
G
T
R
V
Y
F
F
T
Q
E
E
L
D
T
L
F
T
T
A
G
L
E
K
V
Q
N
L
V
D
R
R
L
Q
V
N
R
G
K
Q
L
T
M
Y
R
V
W
I
Q
C
K
Y
C
K
P
L
L
S
S
T
S
50 100 150 200 250 300 350 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: