| Full name: |
tRNA N(3)-methylcytidine methyltransferase |
| Synonym: |
|
| GI: |
None |
| Orf: |
|
| COG: |
|
| UniProt: |
Q6P1Q9 |
| Structures: |
|
|
|
| Complex: |
DALRD3 (for tRNA Arg substrate) |
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
|
Comments:
METTL2B (similarly to METTL2A) mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). The activity of METTL2 towards tRNA substrates is reduced to 1/10 in comparison to METTL2A. METTL2B protein carries 6 single amino acid substitutions comparing to METTL2A (V12I, R26S, P124C, L155P, I266V, M288V).
Protein sequence:
MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEF
PELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ
TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. |
Xu L, Liu X, Sheng N, Oo KS, Liang J, Chionh YH, Xu J, Ye F, Gao YG, Dedon PC, Fu XY |
J Biol Chem |
[details]
|
28655767
|
10.1074/jbc.M117.798298
|
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