Modomics - A Database of RNA Modifications

ID Card:

Full name: Mitochondrial mRNA pseudouridine synthase
GI: 294862493
UniProt: Q6P087
Alpha Fold Predicted Structure: AF-Q6P087-F1
Enzyme type: pseudouridine synthase



Protein sequence:

MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ

Comments:

RPUSD3 catalyzes pseudouridylation of specific mitochondrial mRNAs. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M R A V L A R E M D G R R V L G R F W S G W R R G L G V R P V P E D A G F G T E A R H Q R Q P R G S C Q R S G P L G D Q P F A G L L P K N L S R E E L V D A L R A A V V D R K G P L V T L N K P Q G L P V T G K P G E L T L F S V L P E L S Q S L G L R E Q E L Q V V R A S G K E S S G L V L L S S C P Q T A S R L Q K Y F T H A R R A Q R P T A T Y C A V T D G I P A A S E G K I Q A A L K L E H I D G V N L T V P V K A P S R K D I L E G V K K T L S H F R V V A T G S G C A L V Q L Q P L T V F S S Q L Q V H M V L Q L C P V L G D H M Y S A R V G T V L G Q R F L L P A E N N K P Q R Q V L D E A L L R R L H L T P S Q A A Q L P L H L H L H R L L L P G T R A R D T P V E L L A P L P P Y F S R T L Q C L G L R L Q

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q6P087-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q6P087-F1.cif  
DSSP Secondary Structures   Q6P087.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA EMBO Rep. [details] 27974379 10.15252/embr.201643391
A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Jason D Arroyo,Alexis A Jourdain,Sarah E Calvo,Carmine A Ballarano,John G Doench,David E Root,Vamsi K Mootha Cell Metab [details] 27667664 -