Modomics - A Database of RNA Modifications

Full name:	Mitochondrial mRNA pseudouridine synthase
Synonym:
GI:	None
Orf:
COG:
UniProt:	Q6P087
Structures:	\| \|
Complex:
Enzyme type:	pseudouridine synthase
Position of modification - modification:

Comments:

RPUSD3 catalyzes pseudouridylation of specific mitochondrial mRNAs. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA

Protein sequence:

MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLP
VTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNL
TVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHL
TPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability.	Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA	EMBO Rep.	[details]	27974379	10.15252/embr.201643391
A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.	Jason D Arroyo,Alexis A Jourdain,Sarah E Calvo,Carmine A Ballarano,John G Doench,David E Root,Vamsi K Mootha	Cell Metab	[details]	27667664	-