ID Card:
Full name:
Pseudouridine synthase
GI:
74751577
UniProt:
Q8WWH5
Structures:
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Alpha Fold Predicted Structure:
AF-Q8WWH5-F1
Enzyme type:
pseudouridine synthase
Protein sequence:
MAASEAAVVSSPSLKTDTSPVLETAGTVAAMAATPSARAAAAVVAAAARTGSEARVSKAALATKLLSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGGTLDSAARGVLVVGIGSGTKMLTSMLSGSKRYTAIGELGKATDTLDSTGRVTEEKPYDKITQEDIEGILQKFTGNIMQVPPLYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSISLQKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCANVLELTRTKQGPFTLEEHALPEDKWTIDDIAQSLEHCSSLFPAELALKKSKPESNEQVLSCEYITLNEPKREDDVIKTC
Comments:
TRUB1-dependent mRNA/tRNA pseudouridylation occurs in the nucleus. Characterization of TRUB1 targets demonstrates the requirement for a well-defined stem and loop structure for achieving pseudouridylation.
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
A
S
E
A
A
V
V
S
S
P
S
L
K
T
D
T
S
P
V
L
E
T
A
G
T
V
A
A
M
A
A
T
P
S
A
R
A
A
A
A
V
V
A
A
A
A
R
T
G
S
E
A
R
V
S
K
A
A
L
A
T
K
L
L
S
L
S
G
V
F
A
V
H
K
P
K
G
P
T
S
A
E
L
L
N
R
L
K
E
K
L
L
A
E
A
G
M
P
S
P
E
W
T
K
R
K
K
Q
T
L
K
I
G
H
G
G
T
L
D
S
A
A
R
G
V
L
V
V
G
I
G
S
G
T
K
M
L
T
S
M
L
S
G
S
K
R
Y
T
A
I
G
E
L
G
K
A
T
D
T
L
D
S
T
G
R
V
T
E
E
K
P
Y
D
K
I
T
Q
E
D
I
E
G
I
L
Q
K
F
T
G
N
I
M
Q
V
P
P
L
Y
S
A
L
K
K
D
G
Q
R
L
S
T
L
M
K
R
G
E
V
V
E
A
K
P
A
R
P
V
T
V
Y
S
I
S
L
Q
K
F
Q
P
P
F
F
T
L
D
V
E
C
G
G
G
F
Y
I
R
S
L
V
S
D
I
G
K
E
L
S
S
C
A
N
V
L
E
L
T
R
T
K
Q
G
P
F
T
L
E
E
H
A
L
P
E
D
K
W
T
I
D
D
I
A
Q
S
L
E
H
C
S
S
L
F
P
A
E
L
A
L
K
K
S
K
P
E
S
N
E
Q
V
L
S
C
E
Y
I
T
L
N
E
P
K
R
E
D
D
V
I
K
T
C
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs.
Suzuki T, Suzuki T...
Nucleic Acids Res
[details]
24831542
-
Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA.
Shaoni Mukhopadhyay,Manisha Deogharia,Ramesh Gupta
RNA
[details]
33023933
-
TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code.
Modi Safra,Ronit Nir,Daneyal Farouq,Ilya Vainberg Slutskin,Schraga Schwartz
Genome Res
[details]
28073919
-