ID Card:
| Full name: |
Pseudouridine synthase |
| GI: |
74739707
|
| UniProt: |
O95900 |
| Alpha Fold Predicted Structure: |
AF-O95900-F1 |
| Enzyme type: |
pseudouridine synthase |
Protein sequence:
MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ
Comments:
TRUB2-dependent mRNA/tRNA pseudouridylation occurs in the nucleus
Alpha Fold Predicted Structure:
Clear Selection and Reset Camera
Protein sequence:
M
G
S
A
G
L
S
R
L
H
G
L
F
A
V
Y
K
P
P
G
L
K
W
K
H
L
R
D
T
V
E
L
Q
L
L
K
G
L
N
A
R
K
P
P
A
P
K
Q
R
V
R
F
L
L
G
P
M
E
G
S
E
E
K
E
L
T
L
T
A
T
S
V
P
S
F
I
N
H
P
L
V
C
G
P
A
F
A
H
L
K
V
G
V
G
H
R
L
D
A
Q
A
S
G
V
L
V
L
G
V
G
H
G
C
R
L
L
T
D
M
Y
N
A
H
L
T
K
D
Y
T
V
R
G
L
L
G
K
A
T
D
D
F
R
E
D
G
R
L
V
E
K
T
T
Y
D
H
V
T
R
E
K
L
D
R
I
L
A
V
I
Q
G
S
H
Q
K
A
L
V
M
Y
S
N
L
D
L
K
T
Q
E
A
Y
E
M
A
V
R
G
L
I
R
P
M
N
K
S
P
M
L
I
T
G
I
R
C
L
Y
F
A
P
P
E
F
L
L
E
V
Q
C
M
H
E
T
Q
K
E
L
R
K
L
V
H
E
I
G
L
E
L
K
T
T
A
V
C
T
Q
V
R
R
T
R
D
G
F
F
T
L
D
S
A
L
L
R
T
Q
W
D
L
T
N
I
Q
D
A
I
R
A
A
T
P
Q
V
A
A
E
L
E
K
S
L
S
P
G
L
D
T
K
Q
L
P
S
P
G
W
S
W
D
S
Q
G
P
S
S
T
L
G
L
E
R
G
A
G
Q
Secondary Structure Alphabet
- G: 3-turn helix (310helix)
- H: α-helix
- I: 𝝅-helix (5 - turn helix)
- T: Hydrogen Bonded Turn
- B: β-sheet
- S: Bend
- C: Coil (residues not present in any of the above conformations)
- N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs. |
Suzuki T, Suzuki T... |
Nucleic Acids Res |
[details]
|
24831542
|
-
|
| A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. |
Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA |
EMBO Rep. |
[details]
|
27974379
|
10.15252/embr.201643391
|
| Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. |
Shaoni Mukhopadhyay,Manisha Deogharia,Ramesh Gupta |
RNA |
[details]
|
33023933
|
-
|