Modomics - A Database of RNA Modifications

Full name:	Pseudouridine synthase
Synonym:
GI:	None
Orf:
COG:
UniProt:	O95900
Structures:	\| \|
Complex:
Enzyme type:	pseudouridine synthase
Position of modification - modification:

Comments:

TRUB2-dependent mRNA/tRNA pseudouridylation occurs in the nucleus

Protein sequence:

MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQ
ASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRP
MNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSP
GLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs.	Suzuki T, Suzuki T...	Nucleic Acids Res	[details]	24831542	-
A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability.	Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA	EMBO Rep.	[details]	27974379	10.15252/embr.201643391
Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA.	Shaoni Mukhopadhyay,Manisha Deogharia,Ramesh Gupta	RNA	[details]	33023933	-