Modomics - A Database of RNA Modifications

ID Card:

Full name:	m7GpppN-mRNA hydrolase
Synonym:	Nucleoside diphosphate-linked moiety X motif 20, mRNA-decapping enzyme 2
GI:	1476413361
UniProt:	Q8IU60
Structures:	\| 5MP0 \| 5QOH \| 5QOI \| 5QOJ \| 5QOK \| 5QOL \| 5QOM \| 5QON \| 5QOO \| 5QOP \| 5QOQ \| 5QOR \| 5QOS \| 5QOT \| 5QOU \| 5QOV \| 5QOW \| 5QOX \| 5QOY \| 5QOZ \| 5QP0 \| 5QP1 \| 5QP2 \| 5QP3 \| 5QP4 \| 5QP5 \| 5QP6 \| 5QP7 \| 5QP8 \| 5QP9 \| 5QPA \| 5QPB \| 5QPC \|
Alpha Fold Predicted Structure:	AF-Q8IU60-F1
Enzyme type:	hydrolase

PDB Structures:

5MP0

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files	5MP0.pdb 5QOH.pdb 5QOI.pdb 5QOJ.pdb 5QOK.pdb 5QOL.pdb 5QOM.pdb 5QON.pdb 5QOO.pdb 5QOP.pdb 5QOQ.pdb 5QOR.pdb 5QOS.pdb 5QOT.pdb 5QOU.pdb 5QOV.pdb 5QOW.pdb 5QOX.pdb 5QOY.pdb 5QOZ.pdb 5QP0.pdb 5QP1.pdb 5QP2.pdb 5QP3.pdb 5QP4.pdb 5QP5.pdb 5QP6.pdb 5QP7.pdb 5QP8.pdb 5QP9.pdb 5QPA.pdb 5QPB.pdb 5QPC.pdb
Pdbx/mmCIF Files	5MP0.cif 5QOH.cif 5QOI.cif 5QOJ.cif 5QOK.cif 5QOL.cif 5QOM.cif 5QON.cif 5QOO.cif 5QOP.cif 5QOQ.cif 5QOR.cif 5QOS.cif 5QOT.cif 5QOU.cif 5QOV.cif 5QOW.cif 5QOX.cif 5QOY.cif 5QOZ.cif 5QP0.cif 5QP1.cif 5QP2.cif 5QP3.cif 5QP4.cif 5QP5.cif 5QP6.cif 5QP7.cif 5QP8.cif 5QP9.cif 5QPA.cif 5QPB.cif 5QPC.cif

Protein sequence:

METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKLQDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL

Comments:

hDcp2 is a decapping enzyme that catalyzes the cleavage of the cap structure on mRNAs. hDcp2 require Mn2+ as a cofactor. hDcp2 activity is specific to N7 -methylated guanosine-containing RNA. The hDcp2 enzyme does not function on the cap structure alone and is not sensitive to competition by cap analogue, suggesting that hDcp2 requires the RNA for cap recognition ( Piccirillo et al. 2003 ).

Alpha Fold Predicted Structure:

Clear Selection and Reset Camera

Protein sequence:

M E T K R V E I P G S V L D D L C S R F I L H I P S E E R D N A I R V C F Q I E L A H W F Y L D F Y M Q N T P G L P Q C G I R D F A K A V F S H C P F L L P Q G E D V E K V L D E W K E Y K M G V P T Y G A I I L D E T L E N V L L V Q G Y L A K S G W G F P K G K V N K E E A P H D C A A R E V F E E T G F D I K D Y I C K D D Y I E L R I N D Q L A R L Y I I P G I P K D T K F N P K T R R E I R N I E W F S I E K L P C H R N D M T P K S K L G L A P N K F F M A I P F I R P L R D W L S R R F G D S S D S D N G F S S T G S T P A K P T V E K L S R T K F R H S Q Q L F P D G S P G D Q W V K H R Q P L Q Q K P Y N N H S E M S D L L K G K N Q S M R G N G R K Q Y Q D S P N Q K K R T N G L Q P A K Q Q N S L M K C E K K L H P R K L Q D N F E T D A V Y D L P S S S E D Q L L E H A E G Q P V A C N G H C K F P F S S R A F L S F K F D H N A I M K I L D L

Secondary Structure Alphabet

G: 3-turn helix (3₁₀helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files	AF-Q8IU60-F1.pdb
Alpha Fold Pdbx/mmCIF Files	AF-Q8IU60-F1.cif
DSSP Secondary Structures	Q8IU60.dssp

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Functional characterization of the mammalian mRNA decapping enzyme hDcp2.	Christopher Piccirillo,Richie Khanna,Megerditch Kiledjian	RNA	[details]	12923261	-
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.	Erwin van Dijk,Nicolas Cougot,Sylke Meyer,Sylvie Babajko,Elmar Wahle,Bertrand Séraphin	EMBO J	[details]	12486012	-
Multiple mRNA decapping enzymes in mammalian cells.	Man-Gen Song,You Li,Megerditch Kiledjian	Mol Cell	[details]	21070968	-