Modomics - A Database of RNA Modifications

ID Card:

Full name: m7GpppN-mRNA hydrolase
Synonym: Nucleoside diphosphate-linked moiety X motif 20, mRNA-decapping enzyme 2
GI: 1476413361
UniProt: Q8IU60
Structures: | 5MP0 | 5QOH | 5QOI | 5QOJ | 5QOK | 5QOL | 5QOM | 5QON | 5QOO | 5QOP | 5QOQ | 5QOR | 5QOS | 5QOT | 5QOU | 5QOV | 5QOW | 5QOX | 5QOY | 5QOZ | 5QP0 | 5QP1 | 5QP2 | 5QP3 | 5QP4 | 5QP5 | 5QP6 | 5QP7 | 5QP8 | 5QP9 | 5QPA | 5QPB | 5QPC |
Alpha Fold Predicted Structure: AF-Q8IU60-F1
Enzyme type: hydrolase


PDB Structures:


5MP0

Structure Description:

Title: Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain
Classification: HYDROLASE
Technique: X-Ray Diffraction
Resolution: 1.63
R value free: 0.262
R value observed: 0.214
R value work: 0.212

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   5MP0.pdb   5QOH.pdb   5QOI.pdb   5QOJ.pdb   5QOK.pdb   5QOL.pdb   5QOM.pdb   5QON.pdb   5QOO.pdb   5QOP.pdb   5QOQ.pdb   5QOR.pdb   5QOS.pdb   5QOT.pdb   5QOU.pdb   5QOV.pdb   5QOW.pdb   5QOX.pdb   5QOY.pdb   5QOZ.pdb   5QP0.pdb   5QP1.pdb   5QP2.pdb   5QP3.pdb   5QP4.pdb   5QP5.pdb   5QP6.pdb   5QP7.pdb   5QP8.pdb   5QP9.pdb   5QPA.pdb   5QPB.pdb   5QPC.pdb  
Pdbx/mmCIF Files   5MP0.cif   5QOH.cif   5QOI.cif   5QOJ.cif   5QOK.cif   5QOL.cif   5QOM.cif   5QON.cif   5QOO.cif   5QOP.cif   5QOQ.cif   5QOR.cif   5QOS.cif   5QOT.cif   5QOU.cif   5QOV.cif   5QOW.cif   5QOX.cif   5QOY.cif   5QOZ.cif   5QP0.cif   5QP1.cif   5QP2.cif   5QP3.cif   5QP4.cif   5QP5.cif   5QP6.cif   5QP7.cif   5QP8.cif   5QP9.cif   5QPA.cif   5QPB.cif   5QPC.cif  


Protein sequence:

METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKLQDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL

Comments:

hDcp2 is a decapping enzyme that catalyzes the cleavage of the cap structure on mRNAs. hDcp2 require Mn2+ as a cofactor. hDcp2 activity is specific to N7 -methylated guanosine-containing RNA. The hDcp2 enzyme does not function on the cap structure alone and is not sensitive to competition by cap analogue, suggesting that hDcp2 requires the RNA for cap recognition ( Piccirillo et al. 2003 ).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M E T K R V E I P G S V L D D L C S R F I L H I P S E E R D N A I R V C F Q I E L A H W F Y L D F Y M Q N T P G L P Q C G I R D F A K A V F S H C P F L L P Q G E D V E K V L D E W K E Y K M G V P T Y G A I I L D E T L E N V L L V Q G Y L A K S G W G F P K G K V N K E E A P H D C A A R E V F E E T G F D I K D Y I C K D D Y I E L R I N D Q L A R L Y I I P G I P K D T K F N P K T R R E I R N I E W F S I E K L P C H R N D M T P K S K L G L A P N K F F M A I P F I R P L R D W L S R R F G D S S D S D N G F S S T G S T P A K P T V E K L S R T K F R H S Q Q L F P D G S P G D Q W V K H R Q P L Q Q K P Y N N H S E M S D L L K G K N Q S M R G N G R K Q Y Q D S P N Q K K R T N G L Q P A K Q Q N S L M K C E K K L H P R K L Q D N F E T D A V Y D L P S S S E D Q L L E H A E G Q P V A C N G H C K F P F S S R A F L S F K F D H N A I M K I L D L
50100150200250300350400SequenceGHITSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8IU60-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8IU60-F1.cif  
DSSP Secondary Structures   Q8IU60.dssp  





Publications: