ID Card:
Full name:
ApaH-like phosphatase ALPH1
Orf:
Tb927.6.640
UniProt:
Q583T9
Alpha Fold Predicted Structure:
AF-Q583T9-F1
Enzyme type:
phosphatase
Protein sequence:
MTSSTLLEKLSSLKLSEGARVGGRTFRQGVMSPGTIANVTTTATTNINNTNVASAFASLMEKRQPTGSPAENEGPLRGLIIGSDGSGNNNNSSSNNNNNNNNNNSRSMKHSSNNSSTNSGNDKPIETQAPHRSGVEGSAGKAARKLRSSPRTHQLPDEMREKTSHISAVPRSVALALASASVGVTEQPSVTVEQLMRAAPSANVSSVTSPPRCVPTLPVEPMVVVDREGGPDAVRLATLVSGDPSNPKLIDPIDNVNAHKPIIRTVPPCDYRYIIVGDVHGCPEQLEELLLKVEFQQGKDCLIHVGDLVNKGPDSLAVVQLVQAKGAIGVLGNHDFTLLNCIARVKGKALSQQEEVDPVMRLASTFPQGCEDYIRSLPHILRIPQYNVIVVHAGLNVENSLEKQNVHEIMHLRRLERYTESSNNNNNNCGGKQQRNEKQRLRAVVKGSRGQPWGELWTGPECVVFGHDARAGLQELPFAYGIDTGCVYGGQLTAVVYGRDSPKGKLVSVTGLPKDANERRGLPPPAADVYEKYAEELERLILRPTPRATPAIIGYMQKPTFLSAPPPGSPAASTGSVINNSLRPDSCCSLPAASPSLSARATVRSSGVEQETLLSLLRAGEIRAVMTLMRLPAYESMWLNLLCSEVEGCTESFWIPFVKGVLDGLLNTRQNGEGDDYVEDLLQLVLEACDEFCSVREMAIPQLRKLQQRAEGGDFALPKATVKMLKLTVSPQNA
Comments:
ApaH-like phosphatase (ALPH1) as their major mRNA decapping enzyme in Trypanosoma brucei. The in vitro decapping experiments provide evidence for the decapping mechanism of ALPH1 being fundamentally different from the DCP2-mediated decapping. The data are consistent with ALPH1 leaving either a tri- or a diphosphate at the 5’ end of the decapped mRNA, instead of a monophosphate.
Alpha Fold Predicted Structure:
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Protein sequence:
M
T
S
S
T
L
L
E
K
L
S
S
L
K
L
S
E
G
A
R
V
G
G
R
T
F
R
Q
G
V
M
S
P
G
T
I
A
N
V
T
T
T
A
T
T
N
I
N
N
T
N
V
A
S
A
F
A
S
L
M
E
K
R
Q
P
T
G
S
P
A
E
N
E
G
P
L
R
G
L
I
I
G
S
D
G
S
G
N
N
N
N
S
S
S
N
N
N
N
N
N
N
N
N
N
S
R
S
M
K
H
S
S
N
N
S
S
T
N
S
G
N
D
K
P
I
E
T
Q
A
P
H
R
S
G
V
E
G
S
A
G
K
A
A
R
K
L
R
S
S
P
R
T
H
Q
L
P
D
E
M
R
E
K
T
S
H
I
S
A
V
P
R
S
V
A
L
A
L
A
S
A
S
V
G
V
T
E
Q
P
S
V
T
V
E
Q
L
M
R
A
A
P
S
A
N
V
S
S
V
T
S
P
P
R
C
V
P
T
L
P
V
E
P
M
V
V
V
D
R
E
G
G
P
D
A
V
R
L
A
T
L
V
S
G
D
P
S
N
P
K
L
I
D
P
I
D
N
V
N
A
H
K
P
I
I
R
T
V
P
P
C
D
Y
R
Y
I
I
V
G
D
V
H
G
C
P
E
Q
L
E
E
L
L
L
K
V
E
F
Q
Q
G
K
D
C
L
I
H
V
G
D
L
V
N
K
G
P
D
S
L
A
V
V
Q
L
V
Q
A
K
G
A
I
G
V
L
G
N
H
D
F
T
L
L
N
C
I
A
R
V
K
G
K
A
L
S
Q
Q
E
E
V
D
P
V
M
R
L
A
S
T
F
P
Q
G
C
E
D
Y
I
R
S
L
P
H
I
L
R
I
P
Q
Y
N
V
I
V
V
H
A
G
L
N
V
E
N
S
L
E
K
Q
N
V
H
E
I
M
H
L
R
R
L
E
R
Y
T
E
S
S
N
N
N
N
N
N
C
G
G
K
Q
Q
R
N
E
K
Q
R
L
R
A
V
V
K
G
S
R
G
Q
P
W
G
E
L
W
T
G
P
E
C
V
V
F
G
H
D
A
R
A
G
L
Q
E
L
P
F
A
Y
G
I
D
T
G
C
V
Y
G
G
Q
L
T
A
V
V
Y
G
R
D
S
P
K
G
K
L
V
S
V
T
G
L
P
K
D
A
N
E
R
R
G
L
P
P
P
A
A
D
V
Y
E
K
Y
A
E
E
L
E
R
L
I
L
R
P
T
P
R
A
T
P
A
I
I
G
Y
M
Q
K
P
T
F
L
S
A
P
P
P
G
S
P
A
A
S
T
G
S
V
I
N
N
S
L
R
P
D
S
C
C
S
L
P
A
A
S
P
S
L
S
A
R
A
T
V
R
S
S
G
V
E
Q
E
T
L
L
S
L
L
R
A
G
E
I
R
A
V
M
T
L
M
R
L
P
A
Y
E
S
M
W
L
N
L
L
C
S
E
V
E
G
C
T
E
S
F
W
I
P
F
V
K
G
V
L
D
G
L
L
N
T
R
Q
N
G
E
G
D
D
Y
V
E
D
L
L
Q
L
V
L
E
A
C
D
E
F
C
S
V
R
E
M
A
I
P
Q
L
R
K
L
Q
Q
R
A
E
G
G
D
F
A
L
P
K
A
T
V
K
M
L
K
L
T
V
S
P
Q
N
A
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
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