Modomics - A Database of RNA Modifications

Full name:	RNA phosphate cyclase
Synonym:
GI:	None
Orf:
COG:
UniProt:	P46849
Structures:	\| 1QHM \| 1QMI \| 3KGD \| 3TUT \| 3TUX \| 3TV1 \| 3TW3 \|
Complex:
Enzyme type:	cyclase
Position of modification - modification:

Comments:

RtcA catalyses adenylylation of 5'-p ends of DNA or RNA strands using RtcA-histidinyl-N-AMP intermediate to form A-pp-DNA and A-pp-RNA product. RtcA is coregulated in an operon with an RNA ligase, RtcB, that splices RNA 5'-OH ends to either 3'-phosphate or 2',3'-cyclic phosphate ends. RtcA might serve an end healing function in an RNA repair pathway, by converting RNA 2'-phosphates, which cannot be spliced by RtcB, to 2',3'-cyclic phosphates that can be sealed.

Protein sequence:

MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTL
VLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGV
PRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEF
TVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Local cerebral glucose consumption during ethanol withdrawal in the rat: effects of single and multiple episodes and previous convulsive seizures.	L Clemmesen,M Ingvar,R Hemmingsen,T G Bolwig	Brain Res	[details]	3401759	-