Modomics - A Database of RNA Modifications

ID Card:

Full name: Decapping nuclease RAI1
GI: 1723981
UniProt: P53063
Alpha Fold Predicted Structure: AF-P53063-F1
Enzyme type: hydrolase



Protein sequence:

MGVSANLFVKQRGSTTALKQPKEIGFYSRTKDEEYLISDDTNLNYYYLPDAELDRKLDLSSGFQKFKDYYKDFEDRCSLRGLLETIESSERHKGKKINADIITFRGIARKLISCAFDSPSFNTVDLRIVSFNGQLFIKEVPEAVNAAKASSATEAGRNINQDLNVFTGYKFETLATLSNPLQYTPREVIEKRTKRIVSHGDEYISVVRTGVGNCKLILGAEVDCIFDFKENGRDNLKHYAELKCTQQVANISDTHKFERKLFRTWLQCFLVGIPRIIYGFKDDHYVLKTVEEFSTEEVPVLLKNNNPQVGSACLEAIKWYGLLTEWLLKMIPRDEDPHSQIRAFKLVFENNHLRLSEIEESDEEYSGLIDGEHILSNGFKEWRKSLK

Comments:

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M G V S A N L F V K Q R G S T T A L K Q P K E I G F Y S R T K D E E Y L I S D D T N L N Y Y Y L P D A E L D R K L D L S S G F Q K F K D Y Y K D F E D R C S L R G L L E T I E S S E R H K G K K I N A D I I T F R G I A R K L I S C A F D S P S F N T V D L R I V S F N G Q L F I K E V P E A V N A A K A S S A T E A G R N I N Q D L N V F T G Y K F E T L A T L S N P L Q Y T P R E V I E K R T K R I V S H G D E Y I S V V R T G V G N C K L I L G A E V D C I F D F K E N G R D N L K H Y A E L K C T Q Q V A N I S D T H K F E R K L F R T W L Q C F L V G I P R I I Y G F K D D H Y V L K T V E E F S T E E V P V L L K N N N P Q V G S A C L E A I K W Y G L L T E W L L K M I P R D E D P H S Q I R A F K L V F E N N H L R L S E I E E S D E E Y S G L I D G E H I L S N G F K E W R K S L K

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P53063-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P53063-F1.cif  
DSSP Secondary Structures   P53063.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke Nat Commun [details] 33139726 -
"NAD-capQ" detection and quantitation of NAD caps. Ewa Grudzien-Nogalska,Jeremy G Bird,Bryce E Nickels,Megerditch Kiledjian RNA [details] 30045887 -
Identification of a quality-control mechanism for mRNA 5'-end capping. Xinfu Jiao,Song Xiang,Chanseok Oh,Charles E Martin,Liang Tong,Megerditch Kiledjian Nature [details] 20802481 -