Modomics - A Database of RNA Modifications

ID Card:

Full name: Decapping and exoribonuclease protein 1
Synonym: YDR370C
GI: 74583559
UniProt: Q06349
Alpha Fold Predicted Structure: AF-Q06349-F1
Enzyme type: hydrolase



Protein sequence:

MSTEQDAVLGLAKDLEGINLLTVPNLERGHQSKLCKEKTTSDSSSSRKPSQQRDNYRKRRPKLICIPYTSFLHTGMHNFLTKPPRDIFHESKEVALFTNGRAYTILRKDLIPNLKESIAELYESSLLEAKKRKVPYLGHDLFANIDEFVPMTISELDSVSPCFSYIENWILDNPGKDFKIGKKFTVVTTRHHIVDLTMHLFNRRNRQTSLIVTYMGAGLLSFCRNVKKDSQMSKEGIYSNDPNMKKICYSGFEFENWVTENSKVADLTGSKCPIFSLVESKLSEEIGLLIRCEMDAFNPVSETNTELKCFAPLSMHNSNHRRKLLKTWVQTGLLPNSDIMIGLRDSHSGQLLDIQWYSRDLLCKKFNHPGLPTNKKELNYNAQIAVEWCHYCIEAICKLVEANISDYSSTKPESFEIGIDTNNAIVITKLKTTPRNVELFGM

Comments:

Dxo1 is a decapping enzyme that hydrolyzes nicotinamide adenine dinucleotide (NAD) from the 5'-end of a set of NAD-capped RNAs. It acts in a non-canonical way removing the entire cap structure of m7G or incompletely capped RNAs (Chang et al. 2012 ).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M S T E Q D A V L G L A K D L E G I N L L T V P N L E R G H Q S K L C K E K T T S D S S S S R K P S Q Q R D N Y R K R R P K L I C I P Y T S F L H T G M H N F L T K P P R D I F H E S K E V A L F T N G R A Y T I L R K D L I P N L K E S I A E L Y E S S L L E A K K R K V P Y L G H D L F A N I D E F V P M T I S E L D S V S P C F S Y I E N W I L D N P G K D F K I G K K F T V V T T R H H I V D L T M H L F N R R N R Q T S L I V T Y M G A G L L S F C R N V K K D S Q M S K E G I Y S N D P N M K K I C Y S G F E F E N W V T E N S K V A D L T G S K C P I F S L V E S K L S E E I G L L I R C E M D A F N P V S E T N T E L K C F A P L S M H N S N H R R K L L K T W V Q T G L L P N S D I M I G L R D S H S G Q L L D I Q W Y S R D L L C K K F N H P G L P T N K K E L N Y N A Q I A V E W C H Y C I E A I C K L V E A N I S D Y S S T K P E S F E I G I D T N N A I V I T K L K T T P R N V E L F G M

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q06349-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q06349-F1.cif  
DSSP Secondary Structures   Q06349.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke Nat Commun [details] 33139726 -