Modomics - A Database of RNA Modifications

Full name:	NAD-capped RNA hydrolase NPY1
Synonym:	NPY1 YGL067W
GI:	None
Orf:
COG:
UniProt:	P53164
Structures:	\| \|
Complex:
Enzyme type:	hydrolase
Position of modification - modification:

Comments:

NAD-RNA decapping enzyme - hydrolyzes the pyrophosphate bond in NAD to yield nicotinamide mononucleotide (NMN) and adenosine monophosphate (AMP).

Protein sequence:

MSTAVTFFGQHVLNRVSFLRCSKEFIKKSLNHDSTVFIPFIEGEALISPENGDLVQLSNSVKSYKNILSAIVPLYTTLLNTTRSRSDESGINVTFLGLLE
GTDSAFNFEWSNISYKGTPYFGLDIRVTESTLFKKVDFEPIFSYPKVTRDHIFKQTNEDASLYSQGKMYLDWLAKYKFCPGCGSPLFPVEAGTKLQCSNE
NRNVYCNVRDARINNVCFPRTDPTVIIALTNSDYSKCCLARSKKRYGDFVLYSTIAGFMEPSETIEEACIREIWEETGISCKNIDIVRSQPWPYPCSLMI
GCLGIVQFNSKNEVINLNHDDELLDAQWFDTTEIIQALDKYAGGYRVPFKNDINLPGSTTIAFQLINHVCENYKNLRKTSSSHL

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast.	Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke	Nat Commun	[details]	33139726	-
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes.	S R AbdelRaheim,J L Cartwright,L Gasmi,A G McLennan	Arch Biochem Biophys	[details]	11361135	-