Modomics - A Database of RNA Modifications

Full name:	NAD-capped RNA hydrolase NudC
Synonym:
GI:	None
Orf:
COG:
UniProt:	P32664
Structures:	\| 1VK6 \| 2GB5 \| 5ISY \| 5IW4 \| 5IW5 \|
Complex:
Enzyme type:	hydrolase
Position of modification - modification:

Comments:

mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. Has preference for mRNAs with a 5'-end purine.

Protein sequence:

MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGY
CGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSL
MTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast.	Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke	Nat Commun	[details]	33139726	-
"NAD-capQ" detection and quantitation of NAD caps.	Ewa Grudzien-Nogalska,Jeremy G Bird,Bryce E Nickels,Megerditch Kiledjian	RNA	[details]	30045887	-
Identification of a quality-control mechanism for mRNA 5'-end capping.	Xinfu Jiao,Song Xiang,Chanseok Oh,Charles E Martin,Liang Tong,Megerditch Kiledjian	Nature	[details]	20802481	-