Modomics - A Database of RNA Modifications

ID Card:

Full name: 18S rRNA aminocarboxypropyltransferase
UniProt: Q9UJK0
Alpha Fold Predicted Structure: AF-Q9UJK0-F1
Enzyme type: methyltransferase



Protein sequence:

MGRRRAARGPGAEGGRPRHLPTRSLEAFAEEVGAALQASVEPGAADGEGGPGPAALPCTLAMWELGHCDPRRCTGRKLARLGLVRCLRLGHRFGGLVLSPVGKQYASPADRQLVAQSGVAVIDCSWARLDETPFGKMRGSHLRLLPYLVAANPVNYGRPYRLSCVEAFAATFCIVGFPDLAVILLRKFKWGKGFLDLNRQLLDKYAACGSPEEVLQAEQEFLANAKESPQEEEIDPFDVDSGREFGNPNRPVASTRLPSDTDDSDASEDPGPGAERGGASSSCCEEEQTQGRGAEARAPAEVWKGIKKRQRD

Comments:

Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxy propyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Meyer et a. 2016 )





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M G R R R A A R G P G A E G G R P R H L P T R S L E A F A E E V G A A L Q A S V E P G A A D G E G G P G P A A L P C T L A M W E L G H C D P R R C T G R K L A R L G L V R C L R L G H R F G G L V L S P V G K Q Y A S P A D R Q L V A Q S G V A V I D C S W A R L D E T P F G K M R G S H L R L L P Y L V A A N P V N Y G R P Y R L S C V E A F A A T F C I V G F P D L A V I L L R K F K W G K G F L D L N R Q L L D K Y A A C G S P E E V L Q A E Q E F L A N A K E S P Q E E E I D P F D V D S G R E F G N P N R P V A S T R L P S D T D D S D A S E D P G P G A E R G G A S S S C C E E E Q T Q G R G A E A R A P A E V W K G I K K R Q R D

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9UJK0-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9UJK0-F1.cif  
DSSP Secondary Structures   Q9UJK0.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans Britta Meyer 1, Jan Philip Wurm 2, Sunny Sharma 3, Carina Immer 2, Denys Pogoryelov 4, Peter Kötter 1, Denis L J Lafontaine 3, Jens Wöhnert 5, Karl-Dieter Entian [details] 27084949 10.1093/nar/gkw244