ID Card:
Full name:
Ribosomal large subunit pseudouridine synthase B
Synonym:
YciL
GI:
1175678
Orf:
yciL, b1269
COG:
COG1187
UniProt:
P37765
Alpha Fold Predicted Structure:
AF-P37765-F1
Enzyme type:
pseudouridine synthase
Position of modification - modification:
l :2605(2605) - Y
Protein sequence:
MSEKLQKVLARAGHGSRREIESIIEAGRVSVDGKIAKLGDRVEVTPGLKIRIDGHLISVRESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPETSSKVAVEKDRRRMKANQIRRAVKRHSQVSGGRRSGGRNNNG
Comments:
The site-specific RluB (formerly YciL) catalyzes the formation of pseudouridine at position 2605 in the stem of helix 93 in Domain V (Peptidyl Transferase Center) of 23S rRNA (pseudourodine at position 2604 is catalyzed by a different multi-site RNA pseudouridine synthase RluC). RluB (but not RluC) belongs to the same subgroup of RNA pseudouridine synthases as E. coli RluE and RluF.
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
E
K
L
Q
K
V
L
A
R
A
G
H
G
S
R
R
E
I
E
S
I
I
E
A
G
R
V
S
V
D
G
K
I
A
K
L
G
D
R
V
E
V
T
P
G
L
K
I
R
I
D
G
H
L
I
S
V
R
E
S
A
E
Q
I
C
R
V
L
A
Y
Y
K
P
E
G
E
L
C
T
R
N
D
P
E
G
R
P
T
V
F
D
R
L
P
K
L
R
G
A
R
W
I
A
V
G
R
L
D
V
N
T
C
G
L
L
L
F
T
T
D
G
E
L
A
N
R
L
M
H
P
S
R
E
V
E
R
E
Y
A
V
R
V
F
G
Q
V
D
D
A
K
L
R
D
L
S
R
G
V
Q
L
E
D
G
P
A
A
F
K
T
I
K
F
S
G
G
E
G
I
N
Q
W
Y
N
V
T
L
T
E
G
R
N
R
E
V
R
R
L
W
E
A
V
G
V
Q
V
S
R
L
I
R
V
R
Y
G
D
I
P
L
P
K
G
L
P
R
G
G
W
T
E
L
D
L
A
Q
T
N
Y
L
R
E
L
V
E
L
P
P
E
T
S
S
K
V
A
V
E
K
D
R
R
R
M
K
A
N
Q
I
R
R
A
V
K
R
H
S
Q
V
S
G
G
R
R
S
G
G
R
N
N
N
G
50 100 150 200 250 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: