Modomics - A Database of RNA Modifications

Full name: Ribosomal large subunit pseudouridine synthase B
Synonym: YciL
GI: 1175678
Orf: yciL, b1269
COG: COG1187
UniProt: P37765
Structures: | |
Enzyme type: pseudouridine synthase
Position of modification - modification: l:2605(2605) - Y


The site-specific RluB (formerly YciL) catalyzes the formation of pseudouridine at position 2605 in the stem of helix 93 in Domain V (Peptidyl Transferase Center) of 23S rRNA (pseudourodine at position 2604 is catalyzed by a different multi-site RNA pseudouridine synthase RluC). RluB (but not RluC) belongs to the same subgroup of RNA pseudouridine synthases as E. coli RluE and RluF.

Protein sequence:


Enzymatic activities:

Reaction Substrate Type Position
U:Y rRNA (r) LSU/23S/prokaryotic cytosol 2605


Title Authors Journal Details PubMed Id DOI
Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. Del Campo M, Kaya Y, Ofengand J RNA [details] 11720289 -
Pseudouridines and pseudouridine synthases of the ribosome. Ofengand J, Malhotra A, Remme J, Gutgsell NS, Del Campo M, Jean-Charles S, Peil L, Kaya Y Cold Spring Harb Symp Quant Biol [details] 12762017 -

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