Modomics - A Database of RNA Modifications

ID Card:

Full name: 28S rRNA (cytosine-C(5))-methyltransferase
UniProt: Q96P11
Alpha Fold Predicted Structure: AF-Q96P11-F1
Enzyme type: methyltransferase



Protein sequence:

MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFLLDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCSLCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVAVIERVEVPR

Comments:

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 3782 (m5C3782) in 28S rRNA (Sharma et al. 2013 , Heissenberger et al. 2019 ) . m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (Janin et al. 2019 , Heissenberger et al. 2019 )





Alpha Fold Predicted Structure:




Parsing response... [376570/387870]


Clear Selection and Reset Camera

Protein sequence:

M G L Y A A A A G V L A G V E S R Q G S I K G L V Y S S N F Q N V K Q L Y A L V C E T Q R Y S A V L D A V I A S A G L L R A E K K L R P H L A K V L V Y E L L L G K G F R G G G G R W K A L L G R H Q A R L K A E L A R L K V H R G V S R N E D L L E V G S R P G P A S Q L P R F V R V N T L K T C S D D V V D Y F K R Q G F S Y Q G R A S S L D D L R A L K G K H F L L D P L M P E L L V F P A Q T D L H E H P L Y R A G H L I L Q D R A S C L P A M L L D P P P G S H V I D A C A A P G N K T S H L A A L L K N Q G K I F A F D L D A K R L A S M A T L L A R A G V S C C E L A E E D F L A V S P S D P R Y H E V H Y I L L D P S C S G S G M P S R Q L E E P G A G T P S P V R L H A L A G F Q Q R A L C H A L T F P S L Q R L V Y S T C S L C Q E E N E D V V R D A L Q Q N P G A F R L A P A L P A W P H R G L S T F P G A E H C L R A S P E T T L S S G F F V A V I E R V E V P R
50100150200250300350400SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q96P11-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q96P11-F1.cif  
DSSP Secondary Structures   Q96P11.dssp  





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