Modomics - A Database of RNA Modifications

ID Card:

Full name: 28S rRNA (cytosine-C(5))-methyltransferase
UniProt: Q8K4F6
Alpha Fold Predicted Structure: AF-Q8K4F6-F1
Enzyme type: methyltransferase



Protein sequence:

MGLYAAAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQESSRPGQAYQVPRFVRVNTLKTRPEDAIDYFKRQGFSYQGRASSLEDLRALKGQHFLLDPLLPELLVFPAQTDLHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLKNQGKIFAFDQDAKRLAAMATLVARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKERLQALAGFQQRALCHALRFPSLQRLVYSTCSLCQEENEDVVQEALQHNSGTFRLAPVLPTWPHRGLSTFPGSEHCLRASPETTLTGGFFIAVFERAEVVPTPAPQTDAMDPEPLSQVPKRKRRRKAAVGASMQPST

Comments:

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 3438 (m5C3438) in 28S rRNA (Heissenberger et al. 2019 ). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity.





Alpha Fold Predicted Structure:




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Protein sequence:

M G L Y A A A A A V L A G V E S R Q G S L K G L V Y S S N F Q N L K Q L Y A L V C E T Q R Y S A V L D A V I A S A G L L R A E K K L R P H L A K V L V Y E L L L G K G F R G G G G R W K A L L G R H Q A R L K A E L A R L K V H R G V S R N E D L L Q E S S R P G Q A Y Q V P R F V R V N T L K T R P E D A I D Y F K R Q G F S Y Q G R A S S L E D L R A L K G Q H F L L D P L L P E L L V F P A Q T D L H E H P L Y R A G H L I L Q D K A S C L P A M L L S P P P G S H V I D A C A A P G N K T S Y I A A L L K N Q G K I F A F D Q D A K R L A A M A T L V A R A G V S C C E L A E K D F L T V S P S D Q R Y S Q V Q Y I L L D P S C S G S G M L S R Q L E E H G E G T P S K E R L Q A L A G F Q Q R A L C H A L R F P S L Q R L V Y S T C S L C Q E E N E D V V Q E A L Q H N S G T F R L A P V L P T W P H R G L S T F P G S E H C L R A S P E T T L T G G F F I A V F E R A E V V P T P A P Q T D A M D P E P L S Q V P K R K R R R K A A V G A S M Q P S T
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8K4F6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8K4F6-F1.cif  
DSSP Secondary Structures   Q8K4F6.dssp  





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