Modomics - A Database of RNA Modifications

ID Card:

Full name: " tRNA (adenosine(37)-C2)-methyltransferase / Ribosomal RNA large subunit methyltransferase N"
UniProt: Q833B6
Alpha Fold Predicted Structure: AF-Q833B6-F1
Enzyme type: methyltransferase



Protein sequence:

MQKESIYGLTREQLVDWFLAHGEKKFRATQVWEWLYTKRVASFSEMSNISKSLMTLLEENFSLNPLKQVIVQEAQDGTVKYLFELPDKNMIETVLMRQEYGLSVCVTTQVGCNIGCTFCASGLLKKQRDLTAGEIVAQIMWVQHYFDERGLDERVSHVVVMGIGEPFDNYANVMNFLRTINDDKGLAIGARHITVSTSGLVPKIREFADSGLQVNLAISLHAPNNEVRTSIMRINRSFPIEKLMAAIDEYIEKTNRRVTFEYIMLSQVNDRPEHAQQLADLLRNKKKLSYVNLIPYNPVSEHDQYSRSSKEAVLKFYDVLKKNGINCVIRKEHGTDIDAACGQLRSKQMKKEKVKNQ

Comments:

Dual-specificity RNA methyltransferase RlmN; RlmN serves as a ROS-sensitive molecular switch that modulates physiological responses to oxidative stress and confers phenotypic resistance to environmental stresses and antimicrobial agents





Alpha Fold Predicted Structure:






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Protein sequence:

M Q K E S I Y G L T R E Q L V D W F L A H G E K K F R A T Q V W E W L Y T K R V A S F S E M S N I S K S L M T L L E E N F S L N P L K Q V I V Q E A Q D G T V K Y L F E L P D K N M I E T V L M R Q E Y G L S V C V T T Q V G C N I G C T F C A S G L L K K Q R D L T A G E I V A Q I M W V Q H Y F D E R G L D E R V S H V V V M G I G E P F D N Y A N V M N F L R T I N D D K G L A I G A R H I T V S T S G L V P K I R E F A D S G L Q V N L A I S L H A P N N E V R T S I M R I N R S F P I E K L M A A I D E Y I E K T N R R V T F E Y I M L S Q V N D R P E H A Q Q L A D L L R N K K K L S Y V N L I P Y N P V S E H D Q Y S R S S K E A V L K F Y D V L K K N G I N C V I R K E H G T D I D A A C G Q L R S K Q M K K E K V K N Q

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q833B6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q833B6-F1.cif  
DSSP Secondary Structures   Q833B6.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis Wei Lin Lee 1, Ameya Sinha 1 2 3, Ling Ning Lam 2 4 5, Hooi Linn Loo 1, Jiaqi Liang 1 6, Peiying Ho 1, Liang Cui 1, Cheryl Siew Choo Chan 1 7, Thomas Begley 8, Kimberly Ann Kline 1 2 4 9, Peter Dedon [details] 37433804 10.1038/s41467-023-39790-x