Modomics - A Database of RNA Modifications

Full name:	RNA cap guanine-N2 methyltransferase
Synonym:
GI:	159108485
Orf:	GL50803_5613
COG:	COG2265
UniProt:	A8BW33
Structures:	\| \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	n:0 - m2,2,7GpppN snoRNA:0 - m2,2,7GpppN

Comments:

Tgs2 is an AdoMet and m7G-dependent methyltransferase.

Protein sequence:

MSTWLLDSKCVERMKWLFSDLPEEKRVMIKMNEVAFFSVTPAVYADEVARMMRTVLALLGKPPYAVIDGTACVGGDTRLLAKHFDMTVAIERDPETYALL
QDNLTTWGVDAKTISGDTAALIPQFWTLIGAVATFSLYLDPPWGGVDYRSQTDIQLTLGSLAVEDVVNRAFEAHLSMKLAVLKLPRNYNCGYLFRKLGKH
EVFRITQGNFFVFFVARRGSRVKEHGRTAMLQLRKAREEAKARSEETKEDGETRGSGE

Enzymatic activities:

Reaction	Substrate	Type	Position
m7G:m2,7G	snoRNA (sno)		1
m7G:m2,7G	snRNA (sn)		1

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).	Hausmann S, Shuman S	J Biol Chem	[details]	16046409	-
Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.	Hausmann S, Ramirez A, Schneider S, Schwer B, Shuman S	Nucleic Acids Res	[details]	17284461	-