Modomics - A Database of RNA Modifications

ID Card:

Full name:	FKBP12-interacting protein of 37 kDa
UniProt:	Q9ZSZ8
Alpha Fold Predicted Structure:	AF-Q9ZSZ8-F1

Protein sequence:

"ProbableregulatorysubunitoftheN6-methyltransferasecomplex,amultiproteincomplexthatmediatesN6-methyladenosine(m6A)methylationatthe5'-[AG]GAC-3'consensussitesofsomemRNAs.
AssociateswithMTA,MTB,VIRandHAKAItoformthem6AwritercomplexwhichisessentialforadenosinemethylationatspecificmRNAsequences.
N6-methyladenosine(m6A)playsaroleinmRNAstability,processing,translationefficiencyandediting.
Essentialproteinrequiredduringendospermdevelopmentandembryogenesis.Involvedinendoreduplication,especiallyintrichomes.Mayplayaroleinsplicingevent."

Comments:

Alpha Fold Predicted Structure:

Clear Selection and Reset Camera

Protein sequence:

" P r o b a b l e r e g u l a t o r y s u b u n i t o f t h e N 6 - m e t h y l t r a n s f e r a s e c o m p l e x , a m u l t i p r o t e i n c o m p l e x t h a t m e d i a t e s N 6 - m e t h y l a d e n o s i n e ( m 6 A ) m e t h y l a t i o n a t t h e 5 ' - [ A G ] G A C - 3 ' c o n s e n s u s s i t e s o f s o m e m R N A s . A s s o c i a t e s w i t h M T A , M T B , V I R a n d H A K A I t o f o r m t h e m 6 A w r i t e r c o m p l e x w h i c h i s e s s e n t i a l f o r a d e n o s i n e m e t h y l a t i o n a t s p e c i f i c m R N A s e q u e n c e s . N 6 - m e t h y l a d e n o s i n e ( m 6 A ) p l a y s a r o l e i n m R N A s t a b i l i t y , p r o c e s s i n g , t r a n s l a t i o n e f f i c i e n c y a n d e d i t i n g . E s s e n t i a l p r o t e i n r e q u i r e d d u r i n g e n d o s p e r m d e v e l o p m e n t a n d e m b r y o g e n e s i s . I n v o l v e d i n e n d o r e d u p l i c a t i o n , e s p e c i a l l y i n t r i c h o m e s . M a y p l a y a r o l e i n s p l i c i n g e v e n t . "

Secondary Structure Alphabet

G: 3-turn helix (3₁₀helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files	AF-Q9ZSZ8-F1.pdb
Alpha Fold Pdbx/mmCIF Files	AF-Q9ZSZ8-F1.cif
DSSP Secondary Structures	Q9ZSZ8.dssp

Publications:

Title	Authors	Details	PubMed Id	DOI
The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication	Laurent Vespa 1, Gilles Vachon, Frédéric Berger, Daniel Perazza, Jean-Denis Faure, Michel He	[details]	15047892	10.1104/pp.103.028050
Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI		[details]	28503769	10.1111/nph.14586
RNA methyltransferases in plants: Breakthroughs in function and evolution	Ricardo Ferraz 1, Sílvia Coimbra 2, Sandra Correia 3, Jorge Canhoto 4	[details]	36502609	10.1016/j.plaphy.2022.12.001