ID Card:
PDB Structures:
5WLC
5WYJ
5WYK
6KE6
6LQP
6LQQ
6LQR
6LQS
6LQT
6LQU
6LQV
6ND4
6ZDT
6ZQA
6ZQB
6ZQC
6ZQD
6ZQE
7AJT
7AJU
}
5WLC
Structure Description:
Abstract of the PDB Structure's related Publication:
The small-subunit processome represents the earliest stable precursor of the eukaryotic small ribosomal subunit. Here we present the cryo-EM structure of the Saccharomyces cerevisiae small-subunit processome at an overall resolution of 3.8 Å, which provides an essentially complete near-atomic model of this assembly. In this nucleolar superstructure, 51 ribosome-assembly factors and two RNAs encapsulate the 18S rRNA precursor and 15 ribosomal proteins in a state that precedes pre-rRNA cleavage at site A1. Extended flexible proteins are employed to connect distant sites in this particle. Molecular mimicry and steric hindrance, as well as protein- and RNA-mediated RNA remodeling, are used in a concerted fashion to prevent the premature formation of the central pseudoknot and its surrounding elements within the small ribosomal subunit.
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Protein sequence:
MAPIEYLLFEEPTGYAVFKVKLQQDDIGSRLKEVQEQINDFGAFTKLIELVSFAPFKGAAEALENANDISEGLVSESLKAILDLNLPKASSKKKNITLAISDKNLGPSIKEEFPYVDCISNELAQDLIRGVRLHGEKLFKGLQSGDLERAQLGLGHAYSRAKVKFSVQKNDNHIIQAIALLDQLDKDINTFAMRVKEWYGWHFPELAKLVPDNYTFAKLVLFIKDKASLNDDSLHDLAALLNEDSGIAQRVIDNARISMGQDISETDMENVCVFAQRVASLADYRRQLYDYLCEKMHTVAPNLSELIGEVIGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSGFISKASAKNKGRISRYLANKCSMASRIDNYSEEPSNVFGSVLKKQVEQRLEFYNTGKPTLKNELAIQEAMELYNKDKPAAEVEETKEKESSKKRKLEDDDEEKKEKKEKKSKKEKKEKKEKKDKKEKKDKKEKKDKKKKSKD
Comments:
Together with Nop58, Snu13 and fibrillarine, they constitute the core of the snoRNA-dependent 2’-O-ribose methyltransferase machinery of RNA.
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
P
I
E
Y
L
L
F
E
E
P
T
G
Y
A
V
F
K
V
K
L
Q
Q
D
D
I
G
S
R
L
K
E
V
Q
E
Q
I
N
D
F
G
A
F
T
K
L
I
E
L
V
S
F
A
P
F
K
G
A
A
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A
L
E
N
A
N
D
I
S
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G
L
V
S
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K
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L
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L
N
L
P
K
A
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S
K
K
K
N
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T
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A
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S
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K
N
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G
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K
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G
L
G
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K
N
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N
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K
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K
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K
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L
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M
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S
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V
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G
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K
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A
A
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D
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis.
Gautier T, Berges T, Tollervey D, Hurt E
Mol Cell Biol
[details]
9372940
-
Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing.
van Nues RW, Granneman S, Kudla G, Sloan KE, Chicken M, Tollervey D, Watkins NJ
EMBO J
[details]
21556049
-
Links: