ID Card:
| Full name: |
Ribosomal RNA large subunit methyltransferase Q |
| Synonym: |
ywdB |
| UniProt: |
P39610 |
| Enzyme type: |
|
| Position of modification - modification: |
:2574(None) - m7G
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAMDPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLKNVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDMIEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTFSAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS
Comments:
RlmQ methylates position 2574 of the 23S rRNA and not ribosomal 50S or 70S particles, suggesting that modification occurs in the early steps of ribosome biogenesis.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
G:m7G
|
rRNA (r) |
rRNA/rRNA/prokaryotic cytosol |
2574 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| The <i>Bacillus subtilis ywbD</i> gene encodes RlmQ, the 23S rRNA methyltransferase forming m<sup>7</sup>G2574 in the A-site of the peptidyl transferase center. |
Wolff P; Labar G; Lechner A; Van Elder D; Soin R; Gueydan C; Kruys V; Droogmans L; Roovers M |
RNA |
[details]
|
38071475
|
10.1261/rna.079853.123
|