ID Card:
| Full name: |
rRNA N6-adenosine-methyltransferase |
| Enzyme type: |
|
| Position of modification - modification: |
:1771(None) - m6A
|
| Level of experimental evidence: |
3 |
| Level of experimental reliability: |
2 |
Protein sequence:
Comments:
Mettl5 is responsible for installing m6A methylation at the 1771 site of the 18S rRNA. ATMETTL5 is ubiquitously expressed and localized in both nucleus and cytoplasm, mediating rRNA m6A methylation. Mechanistically, the loss of ATMETTL5-mediated methylation results in attenuated translation.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
A:m6A
|
rRNA (r) |
rRNA/rRNA/eukaryotic cytosol |
1771 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Methyltransferase ATMETTL5 writes m<sup>6</sup>A on 18S ribosomal RNA to regulate translation in Arabidopsis. |
Song P; Tian E; Cai Z; Chen X; Chen S; Yu K; Bian H; He K; Jia G |
New Phytol |
[details]
|
39188077
|
10.1111/nph.20034
|
| METTL5-mediated 18S rRNA m<sup>6</sup>A modification enhances ribosome assembly and ABA response in <i>Arabidopsis</i>. |
Li P; Zhang Y; Zhang S; Ma J; Fan S; Shen L |
Imeta |
[details]
|
40860432
|
10.1002/imt2.70055
|