| Full name: | Dimethyladenosine transferase |
|---|---|
| Enzyme type: | |
| Position of modification - modification: |
:1735(None) - m6A :1735(None) - m6,6A :1736(None) - m6A :1736(None) - m6,6A |
| Level of experimental evidence: | 2 |
| Level of experimental reliability: | 2 |
nan
DIMT-1 is the methyltransferase required for N6-dimethylation of adenosines 1735 and 1736 on the 18S rRNA. Together with Bud23 (m7G s:1531) those modifications are involved in the inheritance of non-genetic information by altering ribosome heterogeneity rather than through eliciting a general defect in ribosome biogenesis.
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| A:m6A | rRNA (r) | rRNA/rRNA/eukaryotic cytosol | 1735 | |||||||
| m6A:m6,6A | rRNA (r) | rRNA/rRNA/eukaryotic cytosol | 1735 | |||||||
| A:m6A | rRNA (r) | rRNA/rRNA/eukaryotic cytosol | 1736 | |||||||
| m6A:m6,6A | rRNA (r) | rRNA/rRNA/eukaryotic cytosol | 1736 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| 18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis. | Liberman N; Rothi MH; Gerashchenko MV; Zorbas C; Boulias K; MacWhinnie FG; Ying AK; Flood Taylor A; Al Haddad J; Shibuya H; Roach L; Dong A; Dellacona S; Lafontaine DLJ; Gladyshev VN; Greer EL | Mol Cell | [details] | 37689068 | 10.1016/j.molcel.2023.08.014 |
| The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life. | Rothi MH; Sarkar GC; Haddad JA; Mitchell W; Ying K; Pohl N; Sotomayor-Mena RG; Natale J; Dellacona S; Gladyshev VN; Greer EL | Nat Commun | [details] | 40721431 | 10.1038/s41467-025-62323-7 |