Modomics - A Database of RNA Modifications

ID Card:

Full name:	Dimethyladenosine transferase
UniProt:	O59487
Structures:	\| 8X3W \| 8X41 \| 8X44 \| 8X45 \| 8X46 \| 8X47 \| 8X4G \| 8X4I \| 8X4L \| 8X4O \| 8X4P \|
Enzyme type:
Level of experimental evidence:	3
Level of experimental reliability:	3

PDB Structures:

8X3W

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Download RCSB-PDB Structures:

Pdb Files	8X3W.pdb 8X41.pdb 8X44.pdb 8X45.pdb 8X46.pdb 8X47.pdb 8X4G.pdb 8X4I.pdb 8X4L.pdb 8X4O.pdb 8X4P.pdb
Pdbx/mmCIF Files	8X3W.cif 8X41.cif 8X44.cif 8X45.cif 8X46.cif 8X47.cif 8X4G.cif 8X4I.cif 8X4L.cif 8X4O.cif 8X4P.cif

Protein sequence:

MRDRLFFLLSKYGIRPRDSIGQHFLIIEDVIEKAIETANVNENDVILEVGPGLGFLTDELAKRAKKVYTIEIDQKIIEILKKEYSWNNVKIIQGDAVRVEWPKFNKVVSNIPYKISSPFTFKLLKTDFERAVVMYQLEFALRMVAKPGSRNYSRLSLMAQALGNVEIVMKIGKGAFYPRPKVDSALVLIEPRKDKIVLNENLVKALFQHRRKTVPRALKDSIHMLGVSKDEIRGIINNVPHSNKRVFQLYPEEVKDIEEYLKKHGIIS

Comments:

Dimethyladenosine transferase 1 (DIMT1), an ortholog of bacterial KsgA is a conserved protein that assists in ribosome biogenesis by modifying two successive adenosine bases near the 3' end of small subunit (SSU) rRNA.

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Structural and functional characterization of archaeal DIMT1 unveils distinct protein dynamics essential for efficient catalysis.	Saha S; Kanaujia SP	Structure	[details]	39146930	10.1016/j.str.2024.07.013