ID Card:
| Full name: |
tRNA (guanine(46)-N7)-methyltransferase |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - m7G
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
Comments:
The m7G tRNA methyltransferase TrmB is crucial for a top-priority pathogen, Acinetobacter baumannii, to respond to stressors encountered during infection, including oxidative stress, low pH, and iron deprivation. The loss of TrmB dramatically attenuates a murine pulmonary infection.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
G:m7G
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
46 |
|
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|
|
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| The tRNA methyltransferase TrmB is critical for <i>Acinetobacter baumannii</i> stress responses and pulmonary infection. |
McGuffey JC; Jackson-Litteken CD; Di Venanzio G; Zimmer AA; Lewis JM; Distel JS; Kim KQ; Zaher HS; Alfonzo J; Scott NE; Feldman MF |
mBio |
[details]
|
37589464
|
10.1128/mbio.01416-23
|