| Full name: | U6 small nuclear RNA (adenine-(30)-N(6))-methyltransferase |
|---|---|
| UniProt: | F4IGH3 |
| Enzyme type: | |
| Position of modification - modification: |
n:30 - m6A |
| Level of experimental evidence: | 2 |
| Level of experimental reliability: | 2 |
MRSGKKRARSEPGSTKQPRSKYSDNPPDFASLASLYPSFKPFVFFSGSRARIDWTDYNATRELTRVLLLHDHGVNWWIPDGQLCPTVPNRSNYIHWINDLLSSGIIQSLGGDGSKVKGFDIGTGANCIYPLLGASLFGWSFVGSDFTVVALEWAEKNVQSNPHFSDLIEIRDSKVPPQCSSVPEVENTEREKTIQEEAEISATVKSDYHDNKSFIEPAVLLGVVKENETFDFCMSNPPFFETFEEAGLNPKTSCGGTPEEMVCNGGEQAFVSRIIKDSAVLRQRFRWYTSMLGKKANLKLLISKLWEVGVTIVKTTEFVQGQTSRWGLAWSFMPIARKIIAPPVVKKSVLSFMLECIKRQYSAVDVLQSVEEFFKSCGASCKLNSSTFSVDIVASNDQCNTISKNDIADVDSVRSHGYEKQSLDGSSLQVPEYNLSFRILVFQQMPGTLLIKGSLQQKDSPLSGLFSRVFGSLEESLKSKFCRLTLRGKIHRAKLDYPKVVKERERERVLHFT
FIONA1 is an U6 m6A methyltransferase that installs m6A in U6 snRNA and a small subset of poly(A)+ RNA. Disruption of FIONA1 leads to phytochrome signaling-dependent hypocotyl elongation and photoperiod-independent early flowering. FIONA1 can methylate plant mRNA m6A motifs in vitro and in vivo.
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| A:m6A | snRNA (sn) | snRNA/snRNA/eukaryotic nucleoplasm | 30 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering | Chunling Wang # 1, Junbo Yang # 1, Peizhe Song 1, Wei Zhang 1, Qiang Lu 1, Qiong Yu 1, Guifang Jia | [details] | 35101091 | 10.1186/s13059-022-02612-2 | |
| Arabidopsis N6-methyladenosine methyltransferase FIONA1 regulates floral transition by affecting the splicing of FLC and the stability of floral activators SPL3 and SEP3 | Jing Cai 1, Jianzhong Hu 1, Umme Amara 1, Su Jung Park 1, Yuxia Li 2, Daesong Jeong 3, Ilha Lee 3, Tao Xu 2, Hunseung Kang | [details] | 36416766 | 10.1093/jxb/erac461 | |
| FIONA1-mediated mRNA m<sup>6</sup> A methylation regulates the response of Arabidopsis to salt stress. | Cai J; Hu J; Xu T; Kang H | Plant Cell Environ | [details] | 38193282 | 10.1111/pce.14807 |