ID Card:
| Full name: |
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase |
| UniProt: |
Q09357 |
| Structures: |
|
8GU3 |
|
| Enzyme type: |
|
| Position of modification - modification: |
n:43 - m6A
|
| Level of experimental evidence: |
3 |
| Level of experimental reliability: |
2 |
PDB Structures:
8GU3
Structure Description:
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MSQNNEMHPRNPYRNKPPDFKALAVEYPEFRKFCQYVSNGKVTFDFKKDAAVRCLTQTLLKKDFNLDVEIPPGHLVPRVPQKLNYCLLIDDLLKANKLTKNVIGIDIGTGTSCIHALIGARQFNWKFIATDGDEKSVRVAHENVAKNGLSSSICVVHVNPDVKTVLMDVVNTIPDTDYAFCMCNPPFFEKGNGDDKFCEDISSSTETYSNRVASEFRTAPHSATFASSAELFVDGGEVAFVNRIIDDSVLLRDRIKIYTTMIGRKSSLKPLQNRLQRFGDDVKIMISVLNQGKTKRWMLAWTFSKSVSLTTIDRPISFQCPKPGLTRLMQEISILNGRLRQEDTLAIVAEFKCVTWTNQRARKRAKAILSESSIKKAKWNFSNVACQVAFGAGDGKDSYTDAGNFVSSESIPTNNLNAWDNASQAYFPLPNGEVPGPIIRIRIQVFSEDSYDSISFELISGSKQHLHQLVQYLKNLICR
Comments:
METT-10 methylates a variant motif UACm6AGAAAC on the 3′ splice site (AG) of SAM synthetase (SAMS) pre-mRNA.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
A:m6A
|
snRNA (sn) |
snRNA/snRNA/eukaryotic nucleoplasm |
43 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing. |
Mendel M; Delaney K; Pandey RR; Chen KM; Wenda JM; Vågbø CB; Steiner FA; Homolka D; Pillai RS |
Cell |
[details]
|
33930289
|
10.1016/j.cell.2021.03.062
|
| Structure of the Caenorhabditis elegans m6A methyltransferase METT10 that regulates SAM homeostasis. |
Ju J; Aoyama T; Yashiro Y; Yamashita S; Kuroyanagi H; Tomita K |
Nucleic Acids Res |
[details]
|
36794723
|
10.1093/nar/gkad081
|