| Full name: | 12S rRNA N4-methylcytidine (m4C) methyltransferase |
|---|---|
| Synonym: | METT5D1 |
| UniProt: | Q9DCL4 |
| Enzyme type: | |
| Position of modification - modification: |
:840(None) - m4C |
| Level of experimental evidence: | 3 |
| Level of experimental reliability: | 2 |
MLRYPYFYRTYNRLFSHFVDSGASNLDVCPHTIHTAVALHTESKAVEGTALCGPQKVYSSEEKELEAMAKLHIPVMVDQVVHCLAPQKGQVFLDMTFGSGGHTRAILQKEPDVMVYALDRDPVAYAIAEQLSRLYPTQIQALLGQFSQAEALLMKAGVQPGTIDGILMDLGCSSMQLDAPERGFSLRKDGPLDMRMDGDRYPDTPTASDVVNALDQQALASILRAYGEEKHAKKIASAIIQARSTYPISRTQQLASIVAGAFPPSAVYARKDLLQRSTHIATKTFQALRIFVNNELNELYAGLRTAEKFLKTGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSIRQKVKQTSQLDSDQETEERHSVRAPLKWELIHKKVLTPEDQDVQDNPRGRSAKLRAAIKL
METTL15 methyltransferase generates m4C839 in human 12S mtrRNA
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| C:m4C | rRNA (r) | rRNA/rRNA/eukaryotic mitochondria | 840 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. | Ivan Laptev,Ekaterina Shvetsova,Sergey Levitskii,Marina Serebryakova,Maria Rubtsova,Victor Zgoda,Alexey Bogdanov,Piotr Kamenski,Petr Sergiev,Olga Dontsova | Nucleic Acids Res | [details] | 32573735 | - |