ID Card:
| Full name: |
tRNA (guanine(10)-N(2))-dimethyltransferase |
| Synonym: |
HVO_0156 |
| UniProt: |
D4GZA0 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - m2G
t:None - m2,2G
|
| Level of experimental evidence: |
5 |
| Level of experimental reliability: |
5 |
Protein sequence:
MYGLELAGEEDAFAAREAEAAATGVTVVAPGLATARGVEPERARRLAYTRRVVELVGRCAPDIEAARAVVAAANVDREGTVAVRARDVRGLTGISTTDAERELGSALVDRGFGVDLDDPDHELRVCFSEDACLVGWTAVEAVRDFTDRKPTDRPFFQPGSMAPVDARAFVNMAGAEPGARILDPMCGTGGVLLEAGLVGADVVGVDAQAKMVGGARENLRHYVGSGDVVRGDATALPLRDDSMDGAVFDAPYGRQSKIARHSLADLVGGALAEVRRVAPECVMVADRSWAEAAEDAGWGVERVFERRVHRSLVRYVHLLHR
Comments:
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N2) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N2-monomethyl (m2G) or N2-dimethylguanosine (m22G).
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
G:m2G
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
10 |
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m2G:m2,2G
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
10 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes. |
Grosjean H; Gaspin C; Marck C; Decatur WA; de Crécy-Lagard V |
BMC Genomics |
[details]
|
18844986
|
10.1186/1471-2164-9-470
|